Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that different epidermal stem cell populations contribute to the formation of various skin tumors and new hair follicles following β-catenin activation in the adult epidermis.

This study isolated new geranylated coumarins from Mammea siamensis flowers and found that several of these compounds inhibit testosterone 5α-reductase.

This study found that activation of Wnt/β-catenin signaling in mouse testes promotes spermatogonial differentiation and reduces the stem cell pool, with SHISA6 inhibiting this process and maintaining stem cell characteristics.

In this study, researchers observed that African spiny mice, Acomys cahirinus, are capable of regenerating skeletal muscle in dermal wound sites, unlike common mice, Mus musculus.

This study reports previously unrecognized cellular complexity in growing mouse incisors, suggesting species-specific differences in cell dynamics between mouse and human teeth related to growth and differentiation.

This study found that all-trans and 9-cis retinoic acids increase steroid sulfatase activity in HL60 cells through mechanisms involving RARα/RXR heterodimers and multiple signaling pathways.

In this study, Ageratum houstonianum ethanolic extract and its active component agerarin were found to promote hair growth and follicle elongation by increasing SCUBE3 expression via activation of MAPK–AP-1 signaling in human dermal papilla cells, suggesting potential therapeutic value for treating hair loss.

This study found that neonatal Regulatory T cells are crucial for maintaining PPARγ signaling in hair follicles, which supports melanocyte stem cell function and skin pigmentation during early postnatal development.

In this study, researchers developed self-assembled skin models derived from hair follicle cells, offering an ethical and reliable alternative to animal testing and bovine collagen in dermatological research by providing functional dermal and epidermal layers for substance evaluation.

This study found that corticosteroids were the most common treatments for alopecia areata in the USA, but the substantial disease burden suggests a need for more effective options.

In this study, Treg depletion impaired skin wound healing in mice, potentially by altering the cytokine environment and expanding certain T-cell populations, disrupting the normal healing process.

This study found that octahydrobenzo[c]quinolizin-3-one derivatives, particularly compound 3, were potent and selective inhibitors of the enzyme 5α-reductase type 1.

In this study, researchers observed the patterns of hair distribution and scalp anatomy in Chinese young adult males, finding significant variations in hairline shape, hair density, and follicular unit structure.

This review discusses central serous chorioretinopathy, detailing its etiology, associated factors, diagnostic imaging, and therapeutic options, but provides no new clinical findings.

This review discusses the causes, associated conditions, and treatment options for alopecia areata, such as corticosteroids and wigs, but reports no new clinical findings.

This study found that Piper nigrum leaf extract showed in vivo anti-androgenic activity and potent 5α-reductase inhibitory effects, with piperine and (−)-cubebin identified as active components.

This study focused on developing agarose/fucoidan hydrogels for the encapsulation of pancreatic cells, reporting that these materials supported cell viability and self-organization into pseudo-islets over 7 days, highlighting potential for diabetes treatment applications.

In this case study, a 24-year-old female with Parry-Romberg syndrome showed significant craniofacial asymmetry, delayed dental development, and other symptoms without neurological deficits; orthodontic treatment is used to improve occlusion and facial balance.

This study examined the stability of two 5α-reductase inhibitors in Tectona grandis extracts, finding that they are more stable in acidic environments and degrade rapidly under heat and light unless protected, suggesting the need for careful storage when developing anti-hair loss medications.

This study found that artocarpin delivered via alginate/chitosan microparticles effectively suppressed the growth of hamster flank organs compared to artocarpin in solution form, without significant systemic effects.

In this study, nine individuals who underwent rigorous weight loss programs experienced significant hair loss, which researchers attributed to insufficient energy supply to the hair matrix, with regrowth occurring within months.

This review discusses complications from hyaluronic acid filler treatments and explores their causes, presentation, and possible treatment guidelines, without presenting new results.

The researchers reported that red clover extract supplementation in postmenopausal women improved subjective assessments of scalp hair, skin, libido, mood, sleep, and tiredness compared to placebo.

This study found that intracellular Toll-like receptors were significantly up-regulated in peripheral blood mononuclear cells of alopecia areata patients, suggesting a potential role in inflammatory signaling and pathogenesis.

This source suggests that spironolactone, a potassium-sparing diuretic, is underutilized in dermatology despite evidence showing its potential benefits for female acne, hidradenitis suppurativa, and female androgenetic alopecia, noting its long-term safety and reduced need for additional testing in young women.

This study investigated the physicochemical properties of polystyrene-b-poly(acrylic acid) nanovesicles coated with modified chitosans, finding that they can effectively control surface charge and potentially serve as drug delivery carriers with a 50.7% encapsulation efficiency for minoxidil.

This study reported that zinc oxide nanoparticles synthesized using Tridax procumbens leaf extract demonstrated significant antibacterial and anticancer activity, showing potential for applications in biomedical and pharmaceutical fields.

This review explores the causes and mechanisms of alopecia areata and discusses current treatments, reporting no new clinical findings.

This review discusses indole-based bifunctional aldose reductase inhibitors and antioxidants for diabetic complications and chronic inflammation-related pathologies, but reports no new clinical results.

This synthesis report details the successful development of a C-14 labeled isotopomer of LY300502, a 5α-reductase inhibitor, through a multi-step radiochemical process.