Parry-Romberg Syndrome: A Rare Case with Diagnostic Challenges and Orthodontic Implications
September 2025
in “
Cureus
”
Studysummary In this case study, a 24-year-old female with Parry-Romberg syndrome showed significant craniofacial asymmetry, delayed dental development, and other symptoms without neurological deficits; orthodontic treatment is used to improve occlusion and facial balance.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
Parry-Romberg syndrome (PRS) is a rare disorder characterized by progressive hemifacial atrophy, with uncertain etiology involving possible immunological, genetic, and neurovascular factors. This case study discusses a 24-year-old female with PRS, presenting with intraoral and extraoral soft tissue atrophy, localized alopecia, ocular changes, and otologic involvement. Despite significant craniofacial asymmetry, no neurological deficits were observed. The patient is undergoing orthodontic treatment to improve occlusion and facial balance, emphasizing the importance of early recognition and multidisciplinary management. The study calls for further research to understand the long-term effects of orthodontic and surgical interventions in PRS.
