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Finasteride inhibits enzyme activity in rhesus macaques, suggesting they're useful for evaluating similar drugs.

Finasteride and dutasteride are effective for long-term treatment of enlarged prostates but have sexual side effects and a risk of high-grade prostate cancer.

Female mice with disrupted 5α-reductase 1 had significant metabolic issues, including stress response problems, insulin resistance, liver fat buildup, and obesity.

A new method was created to test the effectiveness of Dihydrotestosterone (DHT) inhibitors, like finasteride and dutasteride, in human and fish cells. The results showed fish cells are more sensitive to these treatments, and dutasteride works better than finasteride in all tested cells.

Finasteride effectively blocks rat enzymes, but with varying methods and strength.

5-alpha reductase inhibitors can cause sexual side effects like erectile dysfunction and reduced sexual desire, sometimes lasting after stopping the drug.

Selective non-steroidal inhibitors of 5α-reductase type 1 can help treat DHT-related disorders.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

The enzyme 5α-reductase is key in causing psychotic-like effects from sleep deprivation.

AKR1D1 controls glucocorticoid levels and receptor activity in liver cells.

Finasteride's effect on hair loss and prostate enlargement depends on its binding to an enzyme, with maximum impact at 0.2 mg dose.

Some hair loss and prostate drugs might increase the risk of diabetes and heart disease.

Mice lacking steroid 5α-reductase 2 show less aggression and better impulse control.

Finasteride affects brain processes related to neurotransmission and metabolism, potentially helping with neuropsychiatric conditions.

Certain drugs change freshwater snail shells to a "banana" shape.

Taking 5α-reductase inhibitors with prednisolone can worsen its negative effects on metabolism.

Genetic variations affect dutasteride treatment response for male pattern hair loss.

Plant-based compounds might be a promising alternative for prostate cancer treatment with fewer side effects.

Plant-based compounds might be effective, low-side-effect treatments for prostate cancer by blocking a specific enzyme.

Dutasteride is more effective than Finasteride in reducing prostate size and PSA levels, but both drugs have similar side effects.

The study suggests that analyzing DNA can help treat hair loss, but more research is needed.

The conclusion is that more research is needed to understand if the drug finasteride causes Post-Finasteride Syndrome or if it's due to individual genetic makeup.

5α-reductase inhibitors don't stop bladder cancer from developing or getting worse.

Avicequinone C, a compound found in the Avicennia marina plant, can reduce hair loss by inhibiting a hormone linked to androgenic alopecia.

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

Finasteride, a drug used for certain conditions, can cause serious side effects like sexual dysfunction, suicidal thoughts, and increased diabetes risk, and there's a need for more awareness and research about these effects.

The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.

Finasteride can cause lasting sexual dysfunction, depression, and other side effects, needing more research for treatment.