Notes from the Editor Emeritus: Coincidental Epigenetics or Post-Finasteride Syndrome?

    November 2016 in “ Hair transplant forum international ”
    Dow Stough
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    TLDR The conclusion is that more research is needed to understand if the drug finasteride causes Post-Finasteride Syndrome or if it's due to individual genetic makeup.
    The document discusses a talk given by Dr. Alan Jacobs on "Post-Finasteride Syndrome (PFS)" at the 2016 ISHRS World Congress. PFS is believed to be a side effect of the drug finasteride, primarily causing sexual impairment. Dr. Jacobs presented cases of patients experiencing persistent sexual, emotional, and cognitive impairment after using finasteride. He discussed potential neuroendocrine findings in these cases, including low levels of certain hormones. Dr. Jacobs also mentioned the role of epigenetics in persistent sexual dysfunction after discontinuing certain medications. He highlighted the importance of genetic makeup in how individuals react to finasteride. The talk raised questions about whether PFS is truly caused by finasteride or if it is coincidental due to epigenetics. The document concludes that further study is needed to understand the finasteride syndrome and the potential role of epigenetics.
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