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Certain 4-azasteroids are effective at blocking the enzyme that processes testosterone in human skin and could help treat acne, excessive hair growth, and male pattern baldness.

Selective non-steroidal inhibitors of 5α-reductase type 1 can help treat DHT-related disorders.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

New treatments for prostate cancer and BPH show promise, including novel compounds that target hormone synthesis and response.

LY320236 is a strong blocker of two enzymes that change testosterone into dihydrotestosterone and might help treat conditions related to male hormones.

5α-reductase inhibitors don't stop bladder cancer from developing or getting worse.

Finasteride treatment changes brain steroid levels and receptors, affecting brain function even after stopping treatment.

New treatments for enlarged prostate are being developed to be more effective and have fewer side effects.

5α-Reductase inhibitors do not consistently increase testosterone levels in the blood.

Post-finasteride patients show changed neuroactive steroid levels, possibly causing erectile dysfunction and depression.

PFS and PSSD are similar conditions with persistent sexual dysfunction after stopping medication.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

Higher enzyme levels found in women with hair loss, suggesting hormone imbalance.

Men with early balding showed higher levels of certain genes linked to hair loss and possibly prostate cancer.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

Ginseng, especially red ginseng, may help regrow hair and block a hair loss-related enzyme.

The main enzyme found in pubic skin that could be targeted to treat excessive hair growth is 5 alpha-R2.

Low-dose finasteride reduces excessive hair growth in teenage girls safely and affordably.

Scientists made new substances that can block an enzyme linked to prostate issues and hair loss, with potential for creating a new treatment.

PNU 157706 is a more effective treatment than finasteride for conditions caused by DHT, like enlarged prostate and hair loss.

Post-finasteride syndrome causes lasting sexual, neurological, and physical side effects in some people after taking finasteride.

Hormonal therapy is a treatment option for acne, the only medical treatment for hirsutism, and the most promising for androgenetic alopecia.

Hormones, especially androgens, play a key role in causing acne, and treatments like hormone control pills and hormone-blocking medications can help.

Trazodone and chlorpromazine may help treat sexual dysfunction caused by finasteride and SSRIs.

Different skin cells process testosterone differently, and certain drugs can change this process, possibly helping treat acne and hair loss.

Proscar (finasteride) blocks 5α-reductase in sea urchin ovaries and testes, suggesting potential treatment for androgen-related conditions.

DHT's role in hair loss is important, but measuring its level for diagnosis is questionable.

Plant-based chemicals may help hair growth and prevent hair loss but need more research to compete with current treatments.

Avicennia Marina extract and avicequinone C can reduce hair loss hormone production and increase hair growth factors, suggesting they could be used to treat androgenic alopecia.

Long-term use of finasteride and dutasteride can cause serious health issues like diabetes and liver problems.