Resistance Training Ameliorates Finasteride-Induced Disturbance in Protein Homeostasis in Skeletal Muscle of Rats

May 2019 in “ 운동과학 ”

Sung Yong Oh, Dong Ho Lee, Yoo-Hyun Lee, Jeong-Sun Ju, 성희 오, 동원 이, 유현 이, 정선 주

finasteride resistance exercise protein homeostasis autophagic degradation protein synthesis Propecia

Studysummary This study found that while finasteride alone disturbed protein homeostasis in rat skeletal muscle, resistance exercise appeared to mitigate these effects.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The study investigated the effects of 8-week finasteride treatment and resistance exercise on protein homeostasis in the skeletal muscle of 48 male Sprague Dawley rats. Finasteride significantly reduced protein synthesis and increased autophagic degradation, disturbing protein homeostasis. Resistance exercise increased both protein synthesis and autophagic degradation. When combined, the treatments decreased both protein synthesis and autophagy flux. The results suggested that resistance exercise could alleviate the disruption of protein homeostasis induced by finasteride treatment.

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