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Avicennia Marina extract and avicequinone C can reduce hair loss hormone production and increase hair growth factors, suggesting they could be used to treat androgenic alopecia.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

Different animals have unique versions of the enzyme that changes testosterone into another hormone, which is important for creating effective treatments for prostate and hair loss conditions.

Drugs for hormone-related conditions might help treat mental disorders but could have serious side effects.

5α-Reductase inhibitors can help treat hair loss, acne, and prostate issues by reducing DHT levels.

Finasteride and analogues separated using LC-MS-MS technique.

A drug improved schizophrenia-like symptoms in stressed rats by changing brain steroid levels.

Finasteride effectively treats hair loss and enlarged prostate in men, with mild side effects.

5α-reductase inhibitors can cause serious and possibly lasting sexual and psychological side effects.

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

Androgens, like DHT, affect hair growth and treatments like finasteride may help.

4-(4-Phenoxybenzoyl)benzoic acid derivatives can both increase and decrease certain types of reactive oxygen species, and may be relevant to hair loss.

Enzymes called 5α-reductases have many body functions and need more research to safely use inhibitors.

We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.

Men taking dutasteride or finasteride have a slightly higher risk of developing type 2 diabetes.

Young girls whose mothers have PCOS may have higher activity of a specific enzyme that could lead to developing PCOS later.

FCE 28260 is a stronger and longer-lasting inhibitor of 5α-reductase than finasteride, which may make it a better treatment for certain medical conditions.

Finasteride treats enlarged prostate and hair loss, but may cause side effects in some patients.

New treatments for enlarged prostate are being developed, some of which may be more effective than current medications.

Female mice with disrupted 5α-reductase 1 had significant metabolic issues, including stress response problems, insulin resistance, liver fat buildup, and obesity.

Using finasteride or dutasteride may cause long-lasting erectile dysfunction.

Plant extracts like Avicennia marina, Boehmeria nipononivea, and Camellia sinensis could potentially treat hair loss with fewer side effects than synthetic drugs.

The study found that two enzymes linked to hair loss are located in different parts of the scalp, supporting a common treatment's effectiveness.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

New research is needed to create better drugs that block the enzyme responsible for conditions like male baldness and prostate enlargement.

Saw palmetto extract can block the enzyme that converts testosterone in pig prostate cells.

Blocking the enzyme 5α-reductase can shrink the prostate and help treat enlarged prostate issues.

Researchers developed a model to predict how well certain compounds can block an enzyme related to hair loss and prostate issues, suggesting a 50 mg dose of finasteride might be effective based on lab and body data.

5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.

Lower levels of certain brain chemicals are linked to worse PTSD symptoms in men.