Trazodone and Chlorpromazine: A Proposal Treatment for Post-Finasteride Syndrome and Post-Selective Serotonin Reuptake Inhibitors Syndrome

July 2023 in “ Zenodo (CERN European Organization for Nuclear Research) ”

Eric Almeida Xavier

trazodone chlorpromazine post-finasteride syndrome post-SSRI syndrome alpha-adrenergic antagonist libido erectile function synaptic disconnection finasteride SSRIs Desyrel Thorazine PFS post-SSRI

TLDR Trazodone and chlorpromazine may help treat sexual dysfunction caused by finasteride and SSRIs.

The review article suggests trazodone and chlorpromazine as potential treatments for post-finasteride syndrome (PFS) and post-SSRI syndrome, which involve persistent sexual dysfunction after stopping the causative drugs. Trazodone, due to its alpha-adrenergic antagonist properties, may help restore libido and erectile function by reversing synaptic disconnection caused by finasteride and SSRIs. Chlorpromazine, an antipsychotic with similar properties, also shows promise but may have more restrictions. The article emphasizes trazodone's low cost and known side effects, making it a relatively safe and effective option for these drug-induced sexual dysfunctions. The study is supported by the São Paulo Government Research Support Foundation (FAPESP) and declares no conflict of interest.

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