October 2006 in “Aging Health” Dutasteride effectively treats benign prostatic obstruction, improves urinary flow, reduces prostate size, and may prevent prostate cancer, but can cause sexual side effects.
11 citations,
August 2020 in “Diabetes” Testosterone helps human pancreatic cells increase insulin release.
11 citations,
February 2016 in “Current Medicinal Chemistry” New treatments for prostate cancer and BPH show promise, including novel compounds that target hormone synthesis and response.
165 citations,
December 2002 in “Molecular and Cellular Endocrinology” Male hormones, particularly DHT, are linked to male pattern hair loss, and treatments like finasteride can help, but they don't work for postmenopausal women's hair loss, which may have different causes.
December 2023 in “Scientific Reports” Scientists created cell lines from balding patients and found that cells from the front of the scalp are more affected by hormones that cause hair loss than those from the back.
35 citations,
April 2013 in “Sexual medicine reviews” 5-alpha reductase inhibitors slightly increase the risk of sexual and mood side effects, and breast growth in men.
21 citations,
May 2015 in “The Journal of Steroid Biochemistry and Molecular Biology” Progesterone byproduct 5αP stimulates mammary tumor growth, but finasteride can suppress it.
19 citations,
January 2016 in “Annals of Dermatology” Dutasteride is safe and effective for treating hair loss, but may decrease libido.
195 citations,
February 2007 in “The Journal of Clinical Endocrinology and Metabolism” Dutasteride and finasteride may reduce sperm count and volume but don't affect movement or shape; effects are reversible after stopping.
75 citations,
January 2014 in “Korean Journal of Urology” 5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.
75 citations,
November 1996 in “Fertility and Sterility” Finasteride effectively reduces hair growth in women with idiopathic hirsutism, but requires careful contraception during treatment.
1 citations,
August 2015 in “Current Sexual Health Reports” 5α-reductase inhibitors can cause serious and possibly lasting sexual and psychological side effects.
66 citations,
April 2017 in “International Journal of Andrology” Men taking 5α-reductase inhibitors for enlarged prostate have a higher chance of experiencing reduced sexual desire and erectile dysfunction.
October 2023 in “Annales Academiae Medicae Silesiensis” Saw palmetto extracts might help treat male hair loss and need more research.
31 citations,
January 1995 in “The American journal of medicine” Testosterone and dihydrotestosterone play a role in women's health issues like excess hair and baldness, and treatments blocking these hormones may help.
21 citations,
January 2006 in “Pediatrics” Some diseases can improve the outcomes of other diseases, leading to new treatment possibilities.
17 citations,
October 2015 in “Medicine and Pharmacy Reports” Animal models are crucial for learning about hair loss and finding treatments.
97 citations,
April 2016 in “Andrology” Hormones and metabolism play a complex role in prostate enlargement, and more research is needed to improve diagnosis and treatment.
28 citations,
January 2003 in “Urologic oncology” Suppressing certain hormones might help prevent prostate cancer.
87 citations,
March 2005 in “Journal of Dermatological Science” Asiasari radix extract promotes hair growth and increases protein synthesis and cell proliferation.
75 citations,
October 2002 in “Journal of Dermatological Science” Sophora flavescens extract may help hair grow by affecting growth factors and blocking a hair-related enzyme.
12 citations,
June 2019 in “Psychoneuroendocrinology” Allopregnanolone is needed for certain brain processing issues caused by D1 dopamine receptor activation.
50 citations,
May 2020 in “Journal of Clinical Medicine” Non-binary transgender individuals need personalized hormonal treatments for better well-being and quality of life.
4 citations,
June 2003 in “Fertility and Sterility” Finasteride doesn't affect ovulation in normal women.
27 citations,
November 1998 in “Journal of Endocrinological Investigation” Finasteride significantly reduces hair growth in women with idiopathic hirsutism.
70 citations,
March 2016 in “Urologic Clinics of North America” The document explains how the male reproductive system works, its role in making testosterone, and how conditions like obesity can disrupt it, leading to low testosterone and fertility issues.
47 citations,
September 2016 in “Reviews in endocrine and metabolic disorders” The skin's ability to produce hormones is linked to various skin conditions, and better understanding this process could lead to new treatments.
November 2012 in “Endocrine Practice” Enzymes called 5α-reductases have many body functions and need more research to safely use inhibitors.
44 citations,
July 2012 in “Endocrine Practice” We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.
149 citations,
January 2011 in “Nature reviews. Urology” Hormonal interactions, especially involving DHT and estrogen, play a key role in BPH development and treatment.