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Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

The document concludes that the risk of sexual side effects from 5-alpha-reductase inhibitors is low and often temporary, but more research is needed on potential permanent effects.

5α-reductase inhibitors can interfere with doping tests by masking banned substances.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

Plant-based compounds might be a promising alternative for prostate cancer treatment with fewer side effects.

Accurate protein modeling can help develop new treatments for prostate cancer and other diseases.

Finasteride, when given in high oral doses to pregnant monkeys, caused genital abnormalities in male fetuses, but not in female fetuses or those exposed to intravenous finasteride.

Testosterone helps human pancreatic cells increase insulin release.

Hormonal treatment is effective for women with acne not helped by usual treatments, especially if they have hormonal imbalances.

New treatments for enlarged prostate are being developed to be more effective and have fewer side effects.

The conclusion is that while oral contraceptive pills are effective for PCOS-related high androgen levels, new treatments with fewer side effects are needed.

Many potential alopecia treatments need more testing to confirm they promote acceptable hair growth with minimal side effects.

Higher enzyme levels found in women with hair loss, suggesting hormone imbalance.

Avicennia marina extract and avicequinone C can potentially promote hair growth and treat hair loss by interfering with hair loss mechanisms and boosting growth factors.

Female mice with disrupted 5α-reductase 1 had significant metabolic issues, including stress response problems, insulin resistance, liver fat buildup, and obesity.

LY320236 is a strong blocker of two enzymes that change testosterone into dihydrotestosterone and might help treat conditions related to male hormones.

Avicequinone C, a compound found in the Avicennia marina plant, can reduce hair loss by inhibiting a hormone linked to androgenic alopecia.

Finasteride effectively treats male pattern hair loss with a 1 mg daily dose.

The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.

Solanum nigrum may help treat hair loss.

Avicennia Marina extract and avicequinone C can reduce hair loss hormone production and increase hair growth factors, suggesting they could be used to treat androgenic alopecia.

A new plant extract from Avicennia marina could potentially be used to treat common hair loss.

PNU 157706 is a more effective treatment than finasteride for conditions caused by DHT, like enlarged prostate and hair loss.

Androgens may block hair growth signals, targeting this could treat hair loss.

Dutasteride may protect the brain in early Parkinson's disease.

PFS and PSSD are similar conditions with persistent sexual dysfunction after stopping medication.

The Shen Bai Hair Growing Decoction may help treat hair loss by promoting hair growth and reducing inflammation.

Testosterone is key for male sexual function, and treating hormone imbalances can improve sexual issues.

Finasteride effectively treats male pattern baldness, improving hair growth and density.

Topical drugs and near-infrared light therapy show potential for treating alopecia.