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In this study, researchers found that combining fractional CO2 laser sessions with topical dutasteride was more effective in improving male androgenic alopecia than using the laser treatment alone, as observed through global photo assessments and dermoscopic parameters.

This review discusses hormonal control and treatment options for benign prostatic hyperplasia, highlighting similar efficacy and safety between finasteride and dutasteride, and reports no clinical results; further studies are suggested for new therapeutic agents.

This review discusses the pharmacology of 5-alpha reductase inhibitors, their expanding clinical indications beyond benign prostatic hyperplasia, and notes unresolved claims about their potential role in SARS-CoV-2.

This review discusses the pharmacology and clinical use of finasteride for benign prostatic hyperplasia and reports its effectiveness in reducing prostate size and symptoms, though success varies among patients.

This study suggests that guava leaf extract may inhibit hair loss by downregulating genes involved in androgen synthesis, potentially offering a natural alternative for treating androgenetic alopecia.

This study found that the phytosterols β-sitosterol, stigmasterol, and campesterol have low-to-negligible inhibitory activity against steroidal 5α-reductase type 2 compared to the synthetic inhibitor dutasteride, with β-sitosterol showing the highest activity among the tested phytosterols.

This study evaluated novel steroid compounds for their ability to inhibit 5α-reductase, showing that compound 16a significantly reduced rat prostate weight more than epristeride and exhibited excellent in vitro inhibitory potency, indicating its potential as a lead candidate for further benign prostatic hyperplasia drug research.

In this study, researchers developed a new topical atraric acid formulation, AA-TF#15, which showed a significantly higher drug penetration and increased hair regrowth in mice compared to minoxidil and finasteride treatments, suggesting its potential effectiveness for treating scalp androgenic alopecia.

This study demonstrated a validated UPLC method for analyzing finasteride in low-dose drug products, highlighting methanol content and flow rate as critical factors for method robustness and accuracy.

This review highlights that nanotechnology offers promising avenues for enhancing drug delivery and developing new therapeutic strategies for androgenetic alopecia, though challenges remain in clinical translation and the need for long-term safety studies.

Accurate protein modeling can help develop new treatments for prostate cancer and other diseases.

This study found that men with persistent sexual side effects after using finasteride for androgenetic alopecia had higher androgen receptor expression in certain tissues compared to those who never used the drug.

Allopregnanolone likely doesn't influence ethanol's rewarding effects in these mice.

In this study, the researchers highlighted the availability of new topical and systemic agents with varied mechanisms for treatment, emphasizing that the choice of agent should be tailored to individual needs and the options available in different countries.

This review explores different types of alopecia, the effects on hair appearance and growth, and the conventional treatments available, including minoxidil and finasteride, along with their side effects and the need for future drug development and potential therapies.

This study found that utilizing a clinical pharmacist in perioperative urological services reduced surgical cancellations and resident overtime while improving service efficiency and financial sustainability.

In this study, researchers using QM/MM simulations identified key molecular motions and residue interactions in the enzyme SRD5A2 that significantly influence its catalytic efficiency, demonstrating that specific residues play critical roles in stabilizing transition states and reducing activation barriers.

This study reviews the psychological side effects of finasteride, noting a potential association between 5-AR inhibitors and increased depressive symptoms, but emphasizes that the causal link to suicidal ideation remains unclear; the authors recommend mental health screenings and close monitoring for patients starting this medication.

This study used computer simulations to evaluate the absorption of oral and topical finasteride for treating androgenetic alopecia, finding that topical applications resulted in lower plasma concentrations, suggesting potential viability as a treatment option.

This study developed a simple method to determine finasteride, indapamide, and tiemonium methylsulfate in pharmaceuticals by using their ability to form silver nanoparticles measurable via spectrophotometry.

This case report identified a maculopapular rash in a 76-year-old male, occurring 2 months after starting Finasteride for prostatic hyperplasia, with clinical and histologic evidence suggesting a drug-induced skin eruption.

This study examined the evolutionary and functional homology of steroid 5α-reductase and DET2 proteins, identifying protists as a common ancestor, and discovered a new subclass DET2-like in plants, potentially involved in polyprenol reduction.

Finasteride and dutasteride's effects are mainly due to target binding saturation and slow enzyme turnover.

Neurosteroids may help prevent seizures in epilepsy.

5α-reductase inhibitors may cause persistent sexual dysfunction and depression, needing more research on long-term effects.

In this study using human cell cultures, type 1 5α-reductase was found to vary in both protein heterogeneity and expression levels across different types of skin cells.

This study found that Origanum vulgare extract significantly ameliorated finasteride-induced liver and kidney damage in mice by improving biochemical indices, reducing inflammation, and enhancing antioxidant status in a dose-dependent manner.

This study found no significant genetic association between the 5α-reductase enzyme genes and male pattern baldness, suggesting a polygenic etiology rather than simple inheritance.