Comparative Study Between Fractional CO2 Laser Alone Versus Fractional CO2 Laser Combined With Topical Dutasteride in Treatment of Male Androgenic Alopecia

January 2025 in “ Lasers in Medical Science ”

Sara Ahmed Galal, Mona S. Ali, Hala S.A. Hafiz

fractional CO2 laser topical dutasteride androgenic alopecia single pilosebaceous units AGA Dutasteride

TLDR Combining fractional CO2 laser with topical dutasteride is more effective for treating male hair loss than using the laser alone.

This study involving 30 male patients with androgenic alopecia (AGA) compared the effectiveness of fractional CO2 laser treatment alone versus in combination with topical dutasteride. Both treatments improved hair parameters, but the combination therapy showed superior results, including a significant reduction in single pilosebaceous units and higher patient satisfaction. A negative correlation was found between improvement and both age and duration of AGA in the combination group, indicating better responses in younger patients with shorter AGA duration. Side effects were mild across both groups. The study concludes that combining fractional CO2 laser with topical dutasteride is more effective than laser treatment alone for AGA.

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