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This study demonstrated that prevascularized human skin constructs containing engineered hair follicles can successfully induce human hair growth when grafted onto mice by promoting blood supply to the grafted skin.

In this study, gold nanoparticle-conjugated curcumin and thymoquinone formulations were more effective against melanoma cells in 3D bioprinted scaffolds than free or co-administered phytochemicals, sustaining stress responses and overcoming tumor adaptation barriers.

The researchers suggest that advancements in bioprinting technology are promising but still face challenges in achieving human-scale, clinically applicable tissue constructs.

This paper reviews advancements in 3D human skin models using bioprinting, organoid, and organ-on-a-chip technologies, noting improvements in physiological realism through vascularization and multi-omics data, but also highlighting challenges such as cost and lack of standardization that hinder clinical adoption.

This study demonstrated that using a perfusion culture bioreactor and 3D spheroid culture can enhance corneal endothelial cell expansion and support the construction of tissue-engineered corneal endothelial layers in vitro.

This review highlights the potential of 3D bioprinting in developing functional, patient-specific artificial skin, addressing limitations of traditional skin grafts and advancing regenerative medicine applications.

This chapter reviews bioengineered human hair follicles and discusses the pros and cons of different 3-D bioprinting methods, but reports no new experimental findings.

This review discusses the advancements and challenges in developing in vitro human skin models incorporating components like vasculature for drug testing and disease research, but reports no new clinical results.

In this review, researchers summarize key factors in constructing skin organoids, including cell source and assembly methods, and emphasize advances such as air-liquid interface culture for improving tissue development, aiming to guide standardized protocols and future clinical applications.

This review discusses advances and challenges in skin tissue engineering, focusing on developing 3D constructs for functional skin substitutes, and reports no new clinical results.

A single medium, PRIME AIRLIFT, supports better human hair follicle formation in grafts.

Certain cells around hair follicles help improve skin regeneration for potential use in skin grafts.

In this study, researchers used a CRISPR-based method to correct mutations in the COL7A1 gene in stem cells from RDEB patients, restoring normal collagen expression in engineered skin grafts in mice.

In this perspective, recent advances in regenerative medicine, including bioartificial substitutes and engineered in vitro platforms, are reviewed for their potential to restore human hair follicles, highlighting new technologies like 3D printing, hair-on-a-chip models, and stem cell-derived organoids.

This review examines human-relevant in vitro models for studying pigmentation disorders, identifying both challenges and advancements in replicating human pigmentation processes and disease-specific pathology in vitro.

In this study, researchers demonstrated that using 3D spheroid formation and genetic modification significantly enhanced the hair-inducing capacity of human dermal papilla cells in engineered skin constructs.

This study demonstrated that enhancing human skin constructs with hair follicles through engineered cell organization and vascularization improved hair growth in immunodeficient mice, suggesting potential advances for treating alopecia and chronic wounds.

This study developed an in vitro model revealing that hair follicle spheroids enhanced both sweat gland and hair follicle differentiation within bioprinted scaffolds, while microenvironmental cues supported persistent regeneration.

This study demonstrated that gene-corrected 3D skin constructs from RDEB patient-derived iPSCs, grafted onto immunocompetent mice, showed normal collagen VII expression after two months.

This study constructed a 3D-printed scaffold using sodium alginate, gelatin, and alginate lyase hydrogel, which supports hair follicle regeneration in artificial skin, suggesting a promising strategy for tissue-engineered skin with functional appendages.

This study found that 3D cultured hair follicle-like constructs, which include keratinocytes and dermal papilla cells, showed improved gene expression and cell interactions relevant to hair follicle development.

This study demonstrated that decellularization of rat lungs effectively removed cellular material while preserving the 3D extracellular matrix, which may aid future human lung tissue engineering.

This review summarizes the latest progress and challenges in skin organoid research, emphasizing advancements in organoid construction, applications in disease modeling, and factors affecting tissue maturation, while noting barriers such as vascularization and neural integration that hinder clinical translation.

This review discusses recent advancements in 3D bioprinting for skin regeneration and describes potential improvements for clinical applications, but it reports no new experimental results.

This review examines how skin organoids, derived from stem cells, are constructed to simulate skin functions and are pivotal in wound healing and regeneration, highlighting their promising roles in both research and therapeutic applications.

In this mouse study, researchers reported that a 3D bioprinted hydrogel scaffold containing adipose-derived mesenchymal stem cells and nitric oxide enhanced burn wound healing by promoting neovascularization through the VEGF signaling pathway.

This study found that although three-dimensional bioprinting in plastic and reconstructive surgery is rapidly advancing, complete tissue systems have not yet been successfully printed due to ongoing challenges.

This review highlights the global efforts and challenges in 3D bioprinting for developing skin substitutes, emphasizing the need for standardized protocols to enhance reproducibility and clinical applicability in wound healing and regeneration.

This study suggests that 3D bioprinting may become a practical solution for tissue regeneration and complex wound care, demonstrating improved outcomes over traditional methods in various applications.

This study demonstrates that 3D bioprinting is advancing toward practical use in reconstructive medicine, with promising results in personalized skin grafts, hair regeneration, and burn care, despite existing technical and ethical challenges.