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In this study, cyproterone acetate combined with estradiol dramatically improved hirsutism symptoms and significantly reduced plasma testosterone and androstenedione levels in patients over periods of up to three years.

In this study, females with 5 alpha-reductase-2 deficiency exhibited decreased body hair, normal sebum production, and delayed menarche, suggesting a role for DHT in hair growth and menstrual function.

This study found that serum 3 alpha-Adiol-G levels in men are significantly associated with chest hair density and acne, indicating its role in reflecting androgen activity in peripheral tissues.

This study suggests that in women with androgenic alopecia and men with premature balding, enhanced 5α-reductase activity and altered androgen conjugation, favoring sulfurylation, may be involved in scalp hair loss.

In this study, progesterone showed anticonvulsant effects in mice via a mechanism that is at least partially independent of its metabolism to THP, without significant psychotoxicity.

In this study, germ-free male mice showed altered levels of certain neuroactive steroids in the brain and periphery, suggesting microbiota may influence neuroendocrine pathways that support brain functioning.

This study demonstrated that allopregnanolone administration caused significant scratching in atopic dermatitis mice, and ethanol-induced scratching may be linked to increased brain allopregnanolone levels.

This study suggests that 5-ADIOL-S may contribute to the synthesis of potent androgens in peripheral tissues, and 3 alpha-DIOL-S could be a marker of androgen metabolism in various female patient groups.

This study found that women with PCOS have higher total PSA levels than controls, and the total PSA level correlates positively with testosterone and free androgen index.

This study found that using isotretinoin and acitretin was not linked to a higher risk or severity of COVID-19 in patients undergoing systemic retinoid therapy.

This review highlights the need for a deeper understanding of 5alpha-reductases and neuroactive steroids to reduce potential adverse effects of 5alpha-reductase inhibitors used for conditions like benign prostatic hyperplasia and androgenic alopecia, but reports no new clinical results.

This study suggests that 5alpha-dihydroprogesterone could be an effective, non-sedative anticonvulsant for drug-resistant complex partial seizures, as observed in a rat model.

This study found that a testosterone patch and gel showed bioequivalent testosterone levels in hypogonadal men, but the patch mimicked a natural circadian profile, while the gel resulted in higher dihydrotestosterone levels.

This study found that mange-infected bare-nosed wombats have increased heat loss, higher metabolic rates, altered behavior, and disrupted fatty acid composition compared to healthy individuals.

In this study, daughters of women with PCOS and control daughters showed no significant differences in metabolic and hormonal parameters, but more PCOS daughters exhibited hirsutism at advanced pubertal stages.

This study found that finasteride may effectively reduce hirsutism in women with idiopathic hirsutism, as evidenced by lower Ferriman-Gallwey scores and hormone levels, without significant adverse effects.

This review discusses the potential effectiveness of cell therapy for hair loss, highlighting promising early findings but emphasizing that more research is needed to explore specific therapies like autologous fat grafting and mesenchymal stem cells.

This study reported significant improvements in hair density, diameter, and patient satisfaction after using non-enzymatic stromal vascular fraction treatment for androgenic alopecia over six months.

This article discusses the role of transplantation in hair restoration but reports no new clinical findings.

This study found that estradiol and other sex steroids reduced the capture of monocytes by human endothelial cells in vitro, potentially inhibiting the formation of atherosclerosis by promoting nCAM polysialylation, which interferes with leukocyte tethering to the vascular endothelium.

This review discusses the roles of DNA methylation in skin development and regeneration, highlighting its impact on embryonic skin lineage, homeostasis, and potential therapeutic targets, but reports no new clinical results.

This study found that Wnt3a increased beta-catenin signaling and upregulated specific genes in cultured human dermal papilla cells, enhancing their response to PGE2 and potentially aiding hair growth.

This study found that formalin-induced pain in rats nearly eliminates testosterone in the brain and spinal cord by likely increasing 5α-reductase activity, but normalizes serum levels after 24 hours.

This study highlights the potential benefits of herbal hair oil in improving hair health, controlling frizz, and preventing hair loss, with common ingredients like coconut, sesame, and mustard oils being frequently used.

In this study, researchers identified and examined males with 17 beta-HSD3 deficiency in a highly inbred Arab population, noting genetic findings and the progression of male characteristics despite being raised as females initially.

This report presents a rare case of suspected 3β HSD deficiency in an adult female with symptoms like male pattern hair loss and low testosterone, suggesting a non-classical presentation.

This review discusses how the HSD3B1(1245C) genotype may impact androgen physiology and the progression of castration-resistant prostate cancer, and does not report new experimental results.

This review found that women with idiopathic hirsutism may have increased 5α-reductase activity, as indicated by elevated levels of a dihydrotestosterone-reduced metabolite, but more research is needed to confirm its clinical relevance as a biomarker.

This study found that cyproterone acetate significantly reduced both serum 3α-AdiolG levels and hirsutism scores in women with idiopathic hirsutism, PCOS, or 21-hydroxylase deficiency, suggesting its effectiveness in treating excessive hair growth.