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Glossary17β-Hydroxysteroid Dehydrogenase

enzyme that converts weaker sex hormones into more potent ones

17β-Hydroxysteroid Dehydrogenase (17β-HSD) is an enzyme that plays a crucial role in the metabolism of steroids, including the conversion of weaker sex hormones into more potent ones. For example, it can convert androstenedione to testosterone and estrone to estradiol, which are important processes in regulating various physiological functions such as reproduction, hair growth, and overall hormonal balance.

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research Oxidative Activity of the Type 2 Isozyme of 17β-Hydroxysteroid Dehydrogenase (17β-HSD) Predominates in Human Sebaceous Glands

45 citations , September 1998 in “Journal of Investigative Dermatology”

The enzyme 17β-HSD type 2 mainly performs oxidation in human sebaceous glands, which may help protect against acne.

Minoxidil increases 17β-hydroxysteroid dehydrogenase and 5α-reductase activity of cultured human dermal papilla cells from balding scalp

research Minoxidil increases 17β-hydroxysteroid dehydrogenase and 5α-reductase activity of cultured human dermal papilla cells from balding scalp

34 citations , February 1999 in “Journal of Dermatological Science”

Minoxidil boosts enzymes that help hair growth.

research Curcumin derivatives inhibit testicular 17β-hydroxysteroid dehydrogenase 3

19 citations , April 2010 in “Bioorganic & Medicinal Chemistry Letters”

Curcumin and its derivatives can block an enzyme important for making testosterone, with one derivative being particularly strong.

Glioblastoma cells express crucial enzymes involved in androgen synthesis: 3β‐hydroxysteroid dehydrogenase, 17‐20α‐hydroxylase, 17β‐hydroxysteroid dehydrogenase and 5α‐reductase

research Glioblastoma cells express crucial enzymes involved in androgen synthesis: 3β‐hydroxysteroid dehydrogenase, 17‐20α‐hydroxylase, 17β‐hydroxysteroid dehydrogenase and 5α‐reductase

5 citations , July 2021 in “Endocrinology, diabetes & metabolism”

Glioblastoma cells can make androgens, which might help the tumor grow.

research A Platform for Determining Medicinal Plants with Targeted 17β-Hydroxysteroid Dehydrogenase Modulation for Possible Hair Loss Prevention

February 2024 in “Cosmetics”

The conclusion is that new plant-based treatments for hair loss may work by targeting certain enzymes.

research Azasteroids as inhibitors of testosterone 5α-reductase in mammalian skin

34 citations , February 1993 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology”

Certain 4-azasteroids are effective at blocking the enzyme that processes testosterone in human skin and could help treat acne, excessive hair growth, and male pattern baldness.

research Expression of steroidogenic enzymes in human sebaceous glands

25 citations , June 2014 in “Journal of Endocrinology/Journal of endocrinology”

Human sebaceous glands contain enzymes that affect androgen production and may influence sebum production and acne.

Hydroxysteroid Dehydrogenase (17β -HSD3, 17β-HSD5, and 3α-HSD3) Inhibitors:Extragonadal Regulation of Intracellular Sex Steroid Hormone Levels

research Hydroxysteroid Dehydrogenase (17β -HSD3, 17β-HSD5, and 3α-HSD3) Inhibitors:Extragonadal Regulation of Intracellular Sex Steroid Hormone Levels

20 citations , June 2007 in “Recent Patents on Endocrine, Metabolic & Immune Drug Discovery”

Certain inhibitors can potentially treat prostate cancer and other hormone-dependent conditions by controlling sex hormone levels in cells.

research Gene expression of type 2 17β hydroxysteroid dehydrogenase in scalp hairs of hirsute women

28 citations , September 2003 in “Steroids”

Hirsute women have lower type 2 17β-HSD enzyme levels, which improve with treatment.

research Pre-receptor regulation of the androgen receptor

56 citations , January 2008 in “Molecular and cellular endocrinology”

Two enzymes regulate androgen receptor activity, affecting treatments for androgen insufficiency and benign prostatic hyperplasia.

research PLASMA C19 STEROID SULPHATE LEVELS AND INDICES OF ANDROGEN BIOAVAILABILITY IN FEMALE PATTERN ANDROGENIC ALOPECIA

32 citations , January 1990 in “Clinical Endocrinology”

Women with female pattern hair loss have higher levels of certain androgens, suggesting increased androgen exposure to hair follicles.

research 25 years of ERβ: a personal journey

11 citations , January 2022 in “Journal of molecular endocrinology”

ERβ has potential in treating prostate cancer and neurodegenerative diseases, but human studies are needed before clinical use.

research Mechanism of action of bolandiol (19-nortestosterone-3β,17β-diol), a unique anabolic steroid with androgenic, estrogenic, and progestational activities

11 citations , February 2010 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology”

Bolandiol, a synthetic steroid, builds muscle and bone without greatly affecting sex glands, and works differently from other hormones.

research Recent Advances in Drug Design and Drug Discovery for Androgen- Dependent Diseases

11 citations , March 2016 in “Current Medicinal Chemistry”

New treatments for prostate cancer and BPH show promise, including novel compounds that target hormone synthesis and response.

research Aldo-Keto Reductase (AKR) 1C3 inhibitors: a patent review

70 citations , September 2017 in “Expert opinion on therapeutic patents”

The review suggests that while many AKR1C3 inhibitors show promise for treating certain cancers, more research is needed to confirm their effectiveness in humans.

research Intracrine androgen biosynthesis, metabolism and action revisited

131 citations , April 2018 in “Molecular and Cellular Endocrinology”

The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.

research Clinical biochemistry of dihydrotestosterone

50 citations , February 2013 in “Annals of Clinical Biochemistry”

Understanding how DHT works is important for diagnosing and treating hormone-related disorders.

research Androgens’ Effects across the Lifespan in Men and Animal Models

May 2021 in “IntechOpen eBooks”

Androgens, male hormones, affect physical and mental functions, with a decrease leading to health issues like muscle loss, bone disease, and depression, and more research is needed on long-term effects and treatments.

research Daily intake of alfalfa sprouts, but not broccoli sprouts, influence plasma levels of androgen in middle-aged males

January 2018 in “Journal of translational science”

Eating alfalfa sprouts every day can raise testosterone levels in middle-aged men, but broccoli sprouts don't have this effect.

research New Insights into Testosterone Biosynthesis: Novel Observations from HSD17B3 Deficient Mice

8 citations , December 2022 in “International journal of molecular sciences”

Mice without the enzyme HSD17B3 still produce normal testosterone, suggesting they have different ways to make it compared to humans.

research Epitestosterone

59 citations , October 2003 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology”

Epitestosterone may counteract testosterone's effects and has roles in body processes like prostate growth and hair distribution.

research Intracrine and Myotrophic Roles of 5α-Reductase and Androgens

35 citations , May 2012 in “Medicine and science in sports and exercise”

Muscles can make their own androgens, which may help muscle growth.

research Simultaneous quantitation of nine hydroxy-androgens and their conjugates in human serum by stable isotope dilution liquid chromatography electrospray ionization tandem mass spectrometry

22 citations , January 2017 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology”

A new method accurately measures nine specific hormones in human blood.

research Androgens and ovarian function: translation from basic discovery research to clinical impact

55 citations , August 2019 in “Journal of Endocrinology”

Androgens are important for female fertility and could help in IVF treatment, but also play a role in causing PCOS.

Activity of 17β-(N-Alkyl/arylformamido) and 17β-[(N-Alkyl/aryl) alkyl/arylamido]-4-methyl-4-aza-5α-androstan-3-ones as 5α-Reductase Inhibitors in the Hamster Flank Organ and Ear11The research has been supported by Endorecherche that is seeking patent protection for the new compounds. F. Labrie is President of Endorecherche.

research Activity of 17β-(N-Alkyl/arylformamido) and 17β-[(N-Alkyl/aryl) alkyl/arylamido]-4-methyl-4-aza-5α-androstan-3-ones as 5α-Reductase Inhibitors in the Hamster Flank Organ and Ear11The research has been supported by Endorecherche that is seeking patent protection for the new compounds. F. Labrie is President of Endorecherche.

10 citations , August 1998 in “Journal of Investigative Dermatology”

The compounds tested could potentially treat hair loss and alopecia.

research Pubertal hormones increase hippocampal expression of α4βδ GABAA receptors

5 citations , May 2019 in “Neuroscience letters”

Hormones during puberty increase certain receptors in the brain, and this change is influenced by estrogen levels.

research Expression of mRNA for androgen receptor, 5alpha-reductase and 17beta-hydroxysteroid dehydrogenase in human dermal papilla cells

63 citations , November 1999 in “British journal of dermatology/British journal of dermatology, Supplement”

Hair sensitivity to androgens is partly controlled by specific enzyme expressions in different hair areas.

research Annotated Patent Selections

January 2000 in “Expert Opinion on Therapeutic Patents”

The document highlights various patents for new compounds with potential treatments for multiple diseases, including cancer, hormonal disorders, and diabetes.

research Mice lacking the epidermal retinol dehydrogenases SDR16C5 and SDR16C6 display accelerated hair growth and enlarged meibomian glands

16 citations , November 2019 in “Journal of biological chemistry/The Journal of biological chemistry”

Mice without certain skin enzymes have faster hair growth and bigger eye glands.

research Clinical Efficacy of Topical or Oral Soy Supplementation in Dermatology: A Systematic Review

2 citations , June 2023 in “Journal of clinical medicine”

Soy supplements improve various skin conditions and aging signs, with topical use boosting skin barrier function.