January 2024 in “Journal of Applied Pharmaceutical Science” This study investigates the potential of phytocompounds from Saraca asoca for treating polycystic ovary syndrome (PCOS) by targeting the ovarian steroidogenesis pathway. Using in-silico methods, 56 ligands were analyzed for their binding affinity to key enzymes and receptors involved in hormone production. Procyanidin B2 and leucopelargonidin showed the highest docking scores, indicating strong potential as inhibitors of aromatase and 17-HSD1, which are involved in estrogen and testosterone biosynthesis. The top seven compounds, including procyanidin B2 and leucopelargonidin, met drug-likeness criteria and demonstrated favorable chemical and biological reactivity, suggesting their promise as treatments for hormonal imbalance in PCOS.
January 2002 in “NCSU Libraries Repository (North Carolina State University Libraries)” 17b-Estradiol in skin affects hair growth and tumor promotion.
1 citations
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July 2022 in “Frontiers in Pharmacology” Dutasteride may help protect neurons and reduce inflammation in Parkinson's disease.
14 citations
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December 2010 in “Seminars in Oncology” Rare adrenal cancers that secrete androgens or estrogens have a poor prognosis and are treated primarily with surgery.
6 citations
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June 2006 in “International Journal of Gynecological Pathology” A postmenopausal woman's hormone imbalance and symptoms improved after removing benign ovarian tumors.