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In-Silico Screening of Potential Anti-Androgenic and Anti-Estrogenic Phytocompounds from Saraca Asoca for Polycystic Ovary Syndrome Treatment

research In-silico screening of potential anti-androgenic and anti-estrogenic phytocompounds from Saraca asoca for polycystic ovary syndrome treatment

January 2024 in “Journal of Applied Pharmaceutical Science”

This study identified procyanidin B2 and leucopelargonidin from Saraca asoca as potential inhibitors in PCOS by showing high binding energy scores against key enzymes involved in estrogen and testosterone biosynthesis.

research Anabolic androgenic steroids and carcinogenicity focusing on Leydig cell: a literature review

65 citations , April 2018 in “Oncotarget”

This review discusses the potential carcinogenic effects of anabolic androgenic steroids, particularly regarding Leydig cell tumors, and highlights the need for preventive information campaigns due to associated health risks.

research Young coconut juice can accelerate the healing process of cutaneous wounds

19 citations , December 2012 in “BMC Complementary and Alternative Medicine”

This study demonstrates that young coconut juice appears to have estrogen-like properties that can accelerate wound healing in ovariectomized rats.

research Endocrine Functions of the Testes

3 citations , November 2021 in “IntechOpen eBooks”

This chapter reviews the role of the testes in producing and functioning of testicular androgens and protein hormones, but it presents no new clinical results.

research 17b-Estradiol is Abundant in Skin and Regulates the Hair Follicle Cycle and Mirex Tumor Promotion

January 2002 in “NCSU Libraries Repository (North Carolina State University Libraries)”

This study found that skin is a significant site for estrogen production in mice, impacting both hair cycle regulation and sensitivity to chemical carcinogenesis.

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community Effect of melatonin on aromatase expression

4 upvotes 4 years ago

Melatonin's effect on aromatase expression is unclear, with studies showing both increases and decreases. Hormonal impacts are complex and inconsistent, similar to changing health advice on other substances.

community Androsterone as a Neurosteroid Replacement Strategy for 5α-Reductase Inhibitor–Associated Sexual and Affective Dysfunction

in Research/Science 36 upvotes 2 months ago

Androsterone may help with sexual and affective dysfunction from finasteride by replacing disrupted neurosteroids without increasing androgenic side effects. Controlled testing is needed to confirm its effectiveness and safety.

community Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect

126 upvotes 2 months ago

PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.

community 20MTF Results on the crown from 1 year on estrogen injections

468 upvotes 5 months ago

Estrogen injections significantly improved hair growth, particularly on the crown, after stopping finasteride. Monotherapy with estrogen led to hairline improvement, but also caused sterility and potential feminization effects.

community High estrogen on finasteride, thoughts?

37 upvotes 2 weeks ago

A 29-year-old male has been using finasteride for hair regrowth but is experiencing side effects like low libido and emotional changes, possibly due to high estrogen levels. Suggestions include weight loss, consulting an endocrinologist, switching to topical treatments, or trying dutasteride.

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learn Alfatradiol

Alfatradiol: What does a form of estrogen have to do with hair loss in men? Alfatradiol (17α-estradiol) is a prescription topical hormone, licensed for androgenetic alopecia in Germany but not FDA-approved. The controlled trial evidence is in women, where it produced stabilisation rather than regrowth and was outperformed by minoxidil; no comparable placebo-controlled trial in men appears to have been published.

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