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This study suggests that the expression of the DP2 receptor is higher in balding scalp cells and that its knockdown could inhibit the transition to the catagen phase in cultured human hair follicles, potentially counteracting hair growth inhibition associated with male pattern baldness.

In this study, females with 5 alpha-reductase-2 deficiency exhibited decreased body hair, normal sebum production, and delayed menarche, suggesting a role for DHT in hair growth and menstrual function.

This study identified that blocking the PTGDR2 receptor in human hair follicles in vitro and in mice reversed the hair growth inhibition caused by PGD2, suggesting a potential approach for treating alopecia.

This review discusses idiopathic hirsutism and suggests that combination treatment, including androgen suppression and cosmetic methods, is most effective, but notes that its pathogenesis remains unclear.

This study observed that hirsute females displayed increased S-phase hair bulb cells and decreased G0/1-phase cells compared to healthy females, with a strong correlation between S-phase percentages and DHEA-S levels.

This study found that in rodent models, the ability of D1 dopamine receptor activation to impair sensory gating is facilitated by 5α-reductase type 1, which produces allopregnanolone.

This study found that prostaglandin D2 reduced proliferation in bulge resident K15+ stem cells but not in other K15+ progenitor cells, suggesting differential impacts on hair follicle stem cell niches.

This study developed a new method for synthesizing finasteride that eliminates the need for expensive and toxic chemicals, achieving high purity and a 24.2% yield.

This study measured plasma testosterone glucosiduronate levels and found no overlap in those with hyperandrogenism compared to normal females, despite normal testosterone and dihydrotestosterone levels in half of the affected patients.

This study found that hirsutism and acne are strong predictors of biochemical hyperandrogenism in women with polycystic ovary syndrome.

This study demonstrated that derivatives of dehydroepiandrosterone (2a-b, 3a-f, and 4a-f) significantly reduced viable LNCaP prostate cancer cells, suggesting potential therapeutic use for metastatic prostate cancer, while finasteride did not alter cell viability.

This study found that long-term GnRH agonist administration in premenopausal women with polycystic ovarian disease resulted in persistent suppression of ovarian steroid secretion, while adrenal steroid levels remained unchanged.

This study found that reduced plasma DIAPH1 levels were associated with polycystic ovary syndrome, suggesting DIAPH1 as a potential predictive factor for the condition.

This study found that some synthesized heterocyclic derivatives showed promising 5α-reductase inhibitor, antiviral, and anti-tumor activities, surpassing several reference drugs in effectiveness.

This study suggests that topical finasteride may benefit women with facial hirsutism, based on observations from a small sample.

This study found that spironolactone reduced androgenic hormones in hirsute women but had only marginal effects on hair growth, making it no more advisable than other therapies.

This study found that in pregnant rats, the suppression of ACTH responses to IL-1β is linked to the action of endogenous opioids and AP, with AP potentially inducing opioid inhibition through increased pENK-A expression.

This study suggests that both the central biosynthesis and metabolism of progesterone to 3α,5α‐THP in the ventral tegmental area are crucial for facilitating lordosis in female rats.

In this study, treatment with the oral contraceptive containing 30 μg ethinyl oestradiol and 150 μg desogestrel significantly reduced androgen-dependent hair growth in hirsute women over one year.

This study suggests that decreased SHBG levels and increased FAI, free testosterone, and DHEAS concentrations are effective in diagnosing PCOS in epidemiological studies of women of reproductive age.

In this study, researchers characterized a dehydroepiandrosterone hydroxylating enzyme system in hair follicles similar to the liver monooxygenase system, noting its inhibition by carbon monoxide and its dependence on NADPH.

This study found that the total testosterone/dihydrotestosterone ratio correlates with a negative metabolic profile in both women with PCOS and healthy women.

This study found that Diane®, a combination of cyproterone acetate and ethinyl estradiol, is an effective contraceptive and treatment for acne and seborrhea, but less effective for pronounced hair growth.

This study concluded that antimullerian hormone levels are not generally effective for distinguishing late onset congenital adrenal hyperplasia from all hyperandrogenic polycystic ovary syndrome subtypes, except one specific subtype.

This review discusses perceptions and side effects of depot medroxyprogesterone acetate and emphasizes the importance of educating teens to enhance compliance; it reports no new clinical findings.

This study found that women with polycystic ovary syndrome had significantly higher serum lactate dehydrogenase levels and lower levels of cortisol, dopamine, zinc, and vitamin D3 compared to healthy controls.

This study found that in PCOS patients, a lower TT/DHT ratio is associated with regular menstruation, while higher ratios are linked to insulin resistance, suggesting its potential as a biomarker for metabolic severity in these patients.

This study reports the development of novel 4-amido-Δ4,6-steroids as potential inhibitors of 5α-reductase, showing promising in vitro results for conditions like acne and benign prostatic cancer.

This case study from Boston University details a 35-year-old woman diagnosed with congenital adrenal hyperplasia, treated with dexamethasone, leading to normalized androgen levels and successful conception.