Flow Cytometric Analysis of Cell Cycle Kinetics of Anagen Scalp Hair Correlated with Plasma Androgens in Hirsutism

    February 1990 in “ PubMed ”
    Franklin Kiesewetter, H. Schell, Christian Seidel
    TLDR Higher DHEA-S levels in hirsute females affect hair growth phases.
    The study analyzed cell cycle kinetics of anagen scalp hair bulbs in 13 hirsute and 10 healthy females using DNA-flow cytometry. It found that hirsute females had a significant increase in S-phase cells (10.2%) and a decrease in G0/1-phase cells (80.7%) compared to healthy females (S-phase 7.5%, G0/1 phase 86%). A strong correlation was observed between S-phase percentages and dehydroepiandrosterone sulfate (DHEA-S) levels in hirsute females, suggesting that DHEA-S, a weak androgen, influenced hair bulb growth kinetics in androgen-sensitive scalp areas. No correlation was found between testosterone levels and cell cycle data.
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