Cutaneous Manifestations and Their Relationship with Serum Testosterone and DHEAS Levels in Women with Polycystic Ovary Syndrome: A Cross-Sectional Clinical Study

    February 2026 in “ Zenodo (CERN European Organization for Nuclear Research) ”
    Belliappa Pemmanda Raju
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    TLDR Hirsutism and acne indicate high androgen levels in women with PCOS, suggesting early treatment can help.
    This study investigated the relationship between cutaneous manifestations and biochemical hyperandrogenism in 71 women with PCOS. The prevalence of hirsutism, acne, and androgenic alopecia (AGA) was 67%, 65%, and 51%, respectively. Elevated levels of total testosterone (TT), free testosterone (FT), and dehydroepiandrosterone sulfate (DHEAS) were found in 66%, 51%, and 31% of patients, respectively. Significant correlations were observed between hirsutism and FT/DHEAS, acne and FT/TT, and acanthosis nigricans (AN) and insulin. The study concludes that hirsutism and acne are reliable indicators of biochemical hyperandrogenism in women with PCOS, suggesting that early intervention could improve cutaneous symptoms and quality of life.
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