A New Method for Synthesis of Finasteride

January 2011 in “ Zhongguo xin yao zazhi ”

XU Ying-jun

finasteride progesterone bromoform reaction amidation oxidative cleavage ring-closing with ammonia dehydrogenation Propecia

TLDR A new, safer method to make finasteride from progesterone is effective for industrial use.

The study presented a new method for synthesizing finasteride from progesterone, involving a series of chemical reactions such as bromoform reaction, amidation, oxidative cleavage, ring-closing with ammonia, and dehydrogenation. The structure of the synthesized finasteride was confirmed using IR, 1H-NMR, MS, and elemental analysis, achieving a purity of over 99% as detected by HPLC, with a total yield of 24.2%. This method was advantageous for industrial production as it avoided the use of expensive and toxic reagents like platinum oxide, oxalyl chloride, and benzeneseleninic anhydride.

View this study on en.cnki.com.cn →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community Bloodwork before fin/dut impact on progesterone level

in Finasteride/Dutasteride 10 upvotes 1 year ago

A 26-year-old man who had a hair transplant and used minoxidil with good results is now experiencing shedding and considering finasteride. He's concerned about high progesterone and mild erectile dysfunction before starting the treatment.

community Intriguing Molecular Structures and Questions (DHT, Progesterone, Fin, etc)

in Research/Science 8 upvotes 1 year ago

The conversation discusses the molecular structures of compounds that reduce DHT levels, including finasteride and Ashwagandha. It explores the potential of using Ashwagandha topically as a 5a reductase inhibitor.

community Last resort attempt. Studies suggest that finasteride topically actually inhibits up to 52% scalp dht which is smiles to dut 0.5mg daily. This solution contains: fin, min, melatonin and progesterone. Trial started today.

in Research/Science 7 upvotes 3 years ago

The conversation discusses a last-resort hair loss treatment combining topical finasteride, minoxidil, melatonin, and progesterone, with claims that topical finasteride can inhibit up to 52% of scalp DHT. One reply clarifies that progesterone is not an anti-androgen but has anti-androgenic properties because it competes with androgens for receptors.

community Boys I am just a gonner. What on earth is my scalp even going through. Looks like world war 3. Pyril 3 months. Topical melitonin/progesterone/fin, dut, fin, oral min, laser trash, anus stimulation. Nothing. Donor area is decimated 😂.

in Progress Pictures 83 upvotes 3 years ago

Treating Seborrheic Dermatitis, a fungal scalp condition which can cause hair loss. Treatments discussed include antifungal shampoos, cold showers, exfoliating the scalp, taking Vitamin D, and stimulating the prostate through the anus.

community Help On Topical Finasteride 0.3%

in Finasteride/Dutasteride 2 upvotes 1 year ago

A user is seeking advice on a new topical hair loss treatment containing Minoxidil 3%, Finasteride 0.3%, Progesterone 1%, Hydrocortisone butyrate 0.1%, and Ketoconazole 0.5%. They are concerned about the systemic absorption of Finasteride and plan to do blood tests and a spermiogram before starting.

community Blood test 3 days after finasteride. Is it ok?

in Finasteride/Dutasteride 3 upvotes 1 year ago

A user asked if taking a blood test 3 days after starting finasteride would affect the results for Estradiol, FSH, SHBG, Progesterone, and DHEA-S. The conversation is about the timing of blood tests after beginning finasteride treatment.

Related Research

1 / 1 results

research Synthesis of Finasteride, 5α-Reductase Inhibitors

January 2003 in “Natural Science Journal of Xiangtan University”

The improved process makes Finasteride suitable for industrial production.