A New Method for Synthesis of Finasteride

    January 2011 in “ Zhongguo xin yao zazhi ”
    XU Ying-jun
    TLDR A new, safer method to make finasteride from progesterone is effective for industrial use.
    The study presented a new method for synthesizing finasteride from progesterone, involving a series of chemical reactions such as bromoform reaction, amidation, oxidative cleavage, ring-closing with ammonia, and dehydrogenation. The structure of the synthesized finasteride was confirmed using IR, 1H-NMR, MS, and elemental analysis, achieving a purity of over 99% as detected by HPLC, with a total yield of 24.2%. This method was advantageous for industrial production as it avoided the use of expensive and toxic reagents like platinum oxide, oxalyl chloride, and benzeneseleninic anhydride.
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