Synthesis of Finasteride, 5α-Reductase Inhibitors
January 2003
in “
Natural Science Journal of Xiangtan University
”
New to Finasteride? There is a guide in the encyclopedia. Read the guide → Studysummary In this study, researchers improved the synthesis process for finasteride, reducing impurity levels and making it suitable for industrial production.
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The document described the synthesis process of Finasteride, a 5α-reductase inhibitor, from Zaixitongsuan. The process involved several chemical reactions, including amidation, oxidation, cyclization, hydrogenation, and dehydrogenation. Improvements were made to the hydrogenation reactions and the isolation conditions of hydrogenated compounds, successfully controlling the impurity level of the 5 β-isomer to below 2%. The final product met the requirements for pharmaceutical use and was deemed suitable for industrial production.
