Evaluation of Dihydrotestosterone Levels and Total Testosterone to Dihydrotestosterone Ratio with Clinical Symptoms and Metabolic Parameters in Patients with Polycystic Ovary Syndrome

This study examined the relationship between dihydrotestosterone (DHT) levels, the total testosterone-to-DHT (TT/DHT) ratio, and clinical and metabolic features in 30 patients with polycystic ovary syndrome (PCOS). It found that the TT/DHT ratio was significantly lower in patients with regular menstruation compared to those with oligomenorrhea and amenorrhea, and higher in patients with insulin resistance. A moderate positive correlation was observed between DHT levels and body mass index (BMI), and a significant correlation between fasting blood sugar (FBS) and the TT/DHT ratio. The study concludes that the TT/DHT ratio could serve as a useful biomarker for identifying PCOS patients with more severe metabolic issues, though larger studies are needed to confirm these findings.