Evaluation of Dihydrotestosterone Levels and Total Testosterone to Dihydrotestosterone Ratio with Clinical Symptoms and Metabolic Parameters in Patients with Polycystic Ovary Syndrome

November 2025 in “ BMC Endocrine Disorders ”

Asal Ebrahimian, Afshin Moradi, Vahid Kheyri, Farzad Najafipour, Vahideh Sadra

dihydrotestosterone DHT total testosterone TT testosterone to dihydrotestosterone ratio TT/DHT ratio polycystic ovary syndrome PCOS insulin resistance biomarker

Studysummary This study found that in PCOS patients, a lower TT/DHT ratio is associated with regular menstruation, while higher ratios are linked to insulin resistance, suggesting its potential as a biomarker for metabolic severity in these patients. Our plain-language summary of this paper — not a Tressless recommendation.

This study examined the relationship between dihydrotestosterone (DHT) levels, the total testosterone-to-DHT (TT/DHT) ratio, and clinical and metabolic features in 30 patients with polycystic ovary syndrome (PCOS). It found that the TT/DHT ratio was significantly lower in patients with regular menstruation compared to those with oligomenorrhea and amenorrhea, and higher in patients with insulin resistance. A moderate positive correlation was observed between DHT levels and body mass index (BMI), and a significant correlation between fasting blood sugar (FBS) and the TT/DHT ratio. The study concludes that the TT/DHT ratio could serve as a useful biomarker for identifying PCOS patients with more severe metabolic issues, though larger studies are needed to confirm these findings.

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Research cited in this study

5 / 5 results

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