Allopregnanolone Induces Opioid Inhibition of Hypothalamo-Pituitary-Adrenal Axis Responses to Interleukin-1β in Pregnancy

    October 2005 in “ Experimental and Clinical Endocrinology & Diabetes ”
    PJ Brunton, A.P. McKAY, Tomasz Ochędalski, JA Russell
    TLDR Allopregnanolone and opioids together reduce stress hormone responses during pregnancy.
    In this study, researchers investigated the role of allopregnanolone (AP) and opioids in modulating the hypothalamo-pituitary-adrenal (HPA) axis response to interleukin-1β (IL-1β) during late pregnancy. They found that in pregnant rats, the HPA axis response to IL-1β was suppressed, which was linked to the actions of AP and endogenous opioids. By using finasteride to block AP production and naloxone as an opioid antagonist, they observed that both treatments partially restored the adrenocorticotropic hormone (ACTH) response to IL-1β in pregnant rats, suggesting that AP and opioid actions were not independent. In virgin rats, AP treatment reduced ACTH responses, but naloxone restored the response, indicating that AP induced opioid tone. Additionally, AP treatment increased proenkephalin-A (pENK-A) mRNA expression in the nucleus tractus solitarius (NTS), suggesting that AP-induced opioid inhibition of HPA responses in pregnancy might be mediated through up-regulated pENK-A expression in the NTS.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 117 results

      community Finastride is a god send miracle FOR ME

      in Finasteride/Dutasteride  203 upvotes 3 years ago
      . This user experienced positive results from using a combination of minoxidil and finasteride, with no reported side effects after two months. Others have also shared their experiences with both short-term and long-term use of finasteride.

      community Six months of only Dermarolling

      in Progress Pictures  157 upvotes 2 years ago
      User tried dermarolling for hair loss and shared progress pictures. Some suggest adding finasteride and minoxidil, while others debate effectiveness and frequency of dermarolling.

      community Why I deleted my YouTube channel Part I

      in Update  118 upvotes 4 years ago
      A YouTuber named Kevin, also known as Rider_Of_Roach, who deleted his YouTube channel due to personal attacks and controversy surrounding his views on hair loss treatments. He advocated for FDA-approved treatments like finasteride and minoxidil but faced backlash from those who disagreed with him. The conversation also discusses his past trolling behavior and a lawsuit he filed against a website that published false information about him. Despite some disagreements, many viewers appreciated his research-based content and hope to see him return in the future.

    Related Research

    1 / 1 results