The Biochemical and Phenotypic Characterization of Females Homozygous for 5 Alpha-Reductase-2 Deficiency
November 1995
in “
The Journal of Clinical Endocrinology & Metabolism
”
5 alpha-reductase-2 deficiency 5 alpha-dihydrotestosterone DHT testosterone testosterone/DHT ratio estradiol follicular development urinary steroid metabolite ratios 3 alpha,5 alpha-androstanediol glucuronide sebum production 5 alpha-reductase-1 isoenzyme hirsutism menstrual disorders menarche hypothalamic/pituitary ovarian
Studysummary In this study, females with 5 alpha-reductase-2 deficiency exhibited decreased body hair, normal sebum production, and delayed menarche, suggesting a role for DHT in hair growth and menstrual function.
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