Boosting Hair Growth Through Follicular Delivery of Melatonin Through Lecithin-Enhanced Pickering Emulsion Stabilized by Chitosan-Dextran Nanoparticles in Testosterone Induced Androgenic Alopecia Rat Model

    April 2023 in “ International Journal of Pharmaceutics ”
    Asmaa A. Elshall, Amira M. Ghoneim, Nehad M. Abd-elmonsif … Dalia S. Shaker
    Studysummary In this study, melatonin-loaded Pickering emulsions stabilized by chitosan-dextran sulphate nanoparticles and enhanced with lecithin showed improved photostability, antioxidant activity, and follicular delivery in androgenic alopecia-affected rats, potentially rivaling commercial minoxidil for hair loss treatment.
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    Research cited in this study 26

    1. Dihydrotestosterone Inhibits Hair Growth in Mice by Inhibiting Insulin-Like Growth Factor-I Production in Dermal Papillae Growth Hormone & IGF Research · 2024
    2. Ex Vivo Permeation Parameters and Skin Deposition of Melatonin-Loaded Microemulsion for Treatment of Alopecia Future Journal of Pharmaceutical Sciences · 2022
    3. The Inflammatory Aspect of Male and Female Pattern Hair Loss Journal of Inflammation Research · 2020
    4. Hair Follicle Targeting With Curcumin Nanocrystals: Influence of Formulation Properties on Penetration Efficacy Journal of Controlled Release · 2020
    5. Spray-Dried Rosuvastatin Nanoparticles for Promoting Hair Growth AAPS PharmSciTech · 2020
    6. Protective Effects of Melatonin on the Skin: Future Perspectives International Journal of Molecular Sciences · 2019
    7. Caffeic Acid Skin Absorption: Delivery of Microparticles to Hair Follicles Saudi pharmaceutical journal · 2019
    8. Alopecia and Techniques in Hair Restoration: An Overview for the Cosmetic Surgeon Oral and Maxillofacial Surgery · 2019
    9. The Medical and Psychosocial Associations of Alopecia: Recognizing Hair Loss as More Than a Cosmetic Concern American Journal of Clinical Dermatology · 2018
    10. Melatonin Vitamin C-Based Nanovesicles for Treatment of Androgenic Alopecia: Design, Characterization and Clinical Appraisal European Journal of Pharmaceutical Sciences · 2018
    11. Androgenetic Alopecia: A Review and Emerging Treatments Clinical research in dermatology · 2017
    12. Preparation and Characterization of Dutasteride-Loaded Nanostructured Lipid Carriers Coated with Stearic Acid-Chitosan Oligomer for Topical Delivery European Journal of Pharmaceutics and Biopharmaceutics · 2017
    13. Hair Growth Promoting Effect of White Wax and Policosanol from White Wax on the Mouse Model of Testosterone-Induced Hair Loss Biomedicine & Pharmacotherapy · 2017
    14. Androgenetic Alopecia: An Update Of Treatment Options Drugs · 2016
    15. Response to Microneedling Treatment in Men with Androgenetic Alopecia Who Failed to Respond to Conventional Therapy Indian Journal of Dermatology · 2015
    16. Oxidative Stress-Associated Senescence in Dermal Papilla Cells of Men with Androgenetic Alopecia Journal of Investigative Dermatology · 2015
    17. Delivery and Targeting of Nanoparticles into Hair Follicles Therapeutic Delivery · 2014
    18. Quantification of Nanoparticle Uptake Into Hair Follicles in Pig Ear and Human Forearm Journal of Controlled Release · 2014
    19. Melatonin Membrane Receptors in Peripheral Tissues: Distribution and Functions Molecular and Cellular Endocrinology · 2012
    20. Topical Melatonin for Treatment of Androgenetic Alopecia International Journal of Trichology · 2012
    21. Guidelines for the Management of Androgenetic Alopecia (2010) Journal of Dermatology · 2011
    22. 5α-Reductase Inhibition and Hair Growth Promotion of Some Thai Plants Traditionally Used for Hair Treatment Journal of Ethnopharmacology · 2011
    23. Differential Stripping: Determination of the Amount of Topically Applied Substances Penetrated into the Hair Follicles ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2005
    24. Penetration Profile of Microspheres in Follicular Targeting of Terminal Hair Follicles ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2004
    25. Melatonin Increases Anagen Hair Rate in Women With Androgenetic Alopecia or Diffuse Alopecia: Results of a Pilot Randomized Controlled Trial British Journal of Dermatology · 2004
    26. Effects of the Pineal Gland Upon the Hair Cycles in Mice Journal of Investigative Dermatology · 1966