Exosomes And Hair Regeneration: A Systematic Review Of Clinical Evidence Across Alopecia Types And Exosome Sources

    September 2025 in “ Clinical Cosmetic and Investigational Dermatology ”
    Mohammed Al Ameer, Abdulaziz Alnajim, Ali Al Ameer … Enas Al Hadi
    Studysummary This analysis concluded that mesenchymal stem cell-derived exosome therapy may offer a promising and safe approach for hair restoration, especially in androgenetic alopecia, despite limitations in study consistency and size.
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    Research cited in this study 17

    1. A Prospective Study of Exosome Therapy for Androgenetic Alopecia Aesthetic Plastic Surgery · 2025
    2. A Pilot Randomized Controlled Trial Evaluating the Efficacy of an Exosome-Containing Plant Extract Formulation for Treating Male Alopecia Life · 2025
    3. Efficacy of Placental-Derived Mesenchymal Stem Cell Exosome Therapy in Treating Androgenetic Alopecia: A Clinical Trial Study Research Square (Research Square) · 2024
    4. Mesenchymal Stem Cell Exosome Therapy for Acquired Trichorrhexis Nodosa: A Case Series Journal of Cosmetic Dermatology · 2024
    5. Autologous Micrografts Containing Nanovesicles, Exosomes, and Follicle Stem Cells in Androgenetic Alopecia: In Vitro and In Vivo Analysis Through a Multicentric, Observational, Evaluator-Blinded Study Aesthetic Plastic Surgery · 2024
    6. Effectiveness of Exosome Treatment in Androgenetic Alopecia: Outcomes of a Prospective Study Aesthetic Plastic Surgery · 2024
    7. Rose Stem Cell-Derived Exosomes for Hair Regeneration Enhancement via Noninvasive Electroporation in Androgenetic Alopecia Journal of Cosmetic Dermatology · 2024
    8. The Roles of Exosomes in Regulating Hair Follicle Growth Clinical Cosmetic and Investigational Dermatology · 2024
    9. Exosomes Derived Stem Cells as a Modern Therapeutic Approach for Skin Rejuvenation and Hair Regrowth Regenerative Therapy · 2024
    10. Androgenetic Alopecia: Therapy Update Drugs · 2023
    11. Treatment of Persistent Chemotherapy-Induced Hair Loss (Alopecia) With Human Mesenchymal Stromal Cells Exosome Enriched Extracellular Vesicles: A Case Report Heliyon · 2023
    12. Exosome Therapy in Hair Regeneration: A Literature Review of the Evidence, Challenges, and Future Opportunities Journal of cosmetic dermatology · 2022
    13. Effects of Exosomes from Adipose-Derived Stem Cells on Hair Loss: A Retrospective Analysis of 39 Patients Journal of cosmetic dermatology · 2022
    14. Clinical Use of Extracellular Vesicles in the Management of Male and Female Pattern Hair Loss: A Preliminary Retrospective Institutional Review Board Safety and Efficacy Study Aesthetic surgery journal · 2022
    15. Treatment Options for Androgenetic Alopecia: Efficacy, Side Effects, Compliance, Financial Considerations, and Ethics Journal of Cosmetic Dermatology · 2021
    16. Exploring the Potential of Mesenchymal Stem Cell-Derived Exosomes for the Treatment of Alopecia Regenerative Engineering and Translational Medicine · 2021
    17. Chemotherapy-Induced Alopecia Management: Clinical Experience and Practical Advice Journal of Cosmetic Dermatology · 2017