Efficacy of Combinational Therapy Using Topical Minoxidil and Microneedling for the Treatment of Androgenetic Alopecia: A Systematic Review and Meta-Analysis

    March 2023 in “ Research Square (Research Square) ”
    Parsa Abdi, Christian Awad, Michelle R. Anthony … Howard Maibach

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary This meta-analysis suggests that combining minoxidil with microneedling significantly increases total hair count compared to minoxidil alone in patients with androgenetic alopecia, although it did not significantly affect hair diameter.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 28

    1. Randomized Trial of Microneedling Combined With 2% Minoxidil Topical Solution for the Treatment of Female Pattern Hair Loss in a Chinese Population Journal of Cosmetic Dermatology · 2022
    2. Does Topical Minoxidil at Concentrations Higher Than 5% Provide Additional Clinical Benefit? Clinical and Experimental Dermatology · 2022
    3. Efficacy and Safety of 5% Minoxidil Alone, Minoxidil Plus Oral Spironolactone, and Minoxidil Plus Microneedling on Female Pattern Hair Loss: A Prospective, Single-Center, Parallel-Group, Evaluator-Blinded, Randomized Trial Frontiers in Medicine · 2022
    4. Microneedling for Hair Loss Journal of Cosmetic Dermatology · 2021
    5. Minoxidil: A Comprehensive Review Journal of Dermatological Treatment · 2021
    6. SULT1A1 (Minoxidil Sulfotransferase) Enzyme Booster Significantly Improves Response to Topical Minoxidil for Hair Regrowth Journal of Cosmetic Dermatology · 2021
    7. Combination Therapy with Topical Minoxidil and Nano-Microneedle-Assisted Fibroblast Growth Factor for Male Androgenetic Alopecia: A Randomized Controlled Trial in Chinese Patients Chinese Medical Journal · 2020
    8. Sulfotransferase SULT1A1 Activity in Hair Follicle: A Prognostic Marker of Response to Minoxidil Treatment in Androgenetic Alopecia Postepy Dermatologii I Alergologii · 2020
    9. Microneedling in Androgenetic Alopecia: Comparing Two Different Depths of Microneedles Journal of Cosmetic Dermatology · 2020
    10. Usefulness of Home-Use Microneedle Devices in the Treatment of Pattern Hair Loss Journal of cosmetic dermatology · 2020
    11. Randomized Trial of Electrodynamic Microneedling Combined with 5% Minoxidil Topical Solution for Treating Androgenetic Alopecia in Chinese Males and Molecular Mechanistic Study of the Involvement of the Wnt/β-Catenin Signaling Pathway Journal of Dermatological Treatment · 2020
    12. Sulfotransferase Activity in Plucked Hair Follicles Predicts Response to Topical Minoxidil Treatment in Brazilian Female Pattern Hair Loss Patients Dermatologic Therapy · 2019
    13. Efficacy and Safety of a New 10% Topical Minoxidil Versus 5% Topical Minoxidil and Placebo in the Treatment of Male Androgenetic Alopecia: A Trichoscopic Evaluation Journal of Dermatological Treatment · 2019
    14. Minoxidil And Its Use In Hair Disorders: A Review Drug Design Development and Therapy · 2019
    15. Evaluation of Long-Term Efficacy of Finasteride in Korean Men with Androgenetic Alopecia Using the Basic and Specific Classification System Journal of Dermatology · 2018
    16. A Randomized Controlled, Single-Observer Blinded Study to Determine the Efficacy of Topical Minoxidil Plus Microneedling Versus Topical Minoxidil Alone in the Treatment of Androgenetic Alopecia Journal of Cutaneous and Aesthetic Surgery · 2018
    17. Review of Applications of Microneedling in Dermatology Clinical, Cosmetic and Investigational Dermatology · 2017
    18. A Comparative Study of Microneedling with PRP Plus Minoxidil (5%) and Minoxidil (5%) Alone in Androgenetic Alopecia Journal of The American Academy of Dermatology · 2017
    19. Micro-Needling Depth Penetration, Presence of Pigment Particles, and Fluorescein-Stained Platelets: Clinical Usage for Aesthetic Concerns Aesthetic Surgery Journal · 2016
    20. Demographics of Women with Female Pattern Hair Loss and the Effectiveness of Spironolactone Therapy Journal of The American Academy of Dermatology · 2015
    21. Combined Treatment with Oral Finasteride and Topical Minoxidil in Male Androgenetic Alopecia: A Randomized and Comparative Study in Chinese Patients Dermatologic Therapy · 2015
    22. Response to Microneedling Treatment in Men with Androgenetic Alopecia Who Failed to Respond to Conventional Therapy Indian Journal of Dermatology · 2015
    23. Cause of Androgenic Alopecia Plastic and reconstructive surgery. Global open · 2013
    24. A Randomized Evaluator Blinded Study of Effect of Microneedling in Androgenetic Alopecia: A Pilot Study International Journal of Trichology · 2013
    25. Male Androgenetic Alopecia: Population-Based Study in 1,005 Subjects International Journal of Trichology · 2009
    26. An Open, Randomized, Comparative Study of Oral Finasteride and 5% Topical Minoxidil in Male Androgenetic Alopecia Dermatology · 2004
    27. A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 2002
    28. Hair Pain (Trichodynia): Frequency and Relationship to Hair Loss and Patient Gender Dermatology · 2002

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