T REATMENT OF H AIR L OSS

January 1999

V Era H. P Rice

androgenetic alopecia alopecia areata finasteride minoxidil hair-growth cycle Propecia Rogaine

TLDR Finasteride and minoxidil help regrow hair by improving hair thickness and length.

The document discussed the treatment of hair loss, specifically focusing on androgenetic alopecia and alopecia areata, which involved reversible changes in the hair-growth cycle. It highlighted the approval of two drugs, finasteride and minoxidil, which were used to promote hair growth. Both drugs were noted to affect the hair-growth cycle by increasing the length and diameter of existing hair, although they operated through different mechanisms.

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Research cited in this study

47 / 47 results

Changes in Hair Weight and Hair Count in Men with Androgenetic Alopecia After Application of 5% and 2% Topical Minoxidil, Placebo, or No Treatment

research Changes in Hair Weight and Hair Count in Men with Androgenetic Alopecia After Application of 5% and 2% Topical Minoxidil, Placebo, or No Treatment

115 citations , November 1999 in “Journal of The American Academy of Dermatology”

Minoxidil increases hair weight and count temporarily in men with hair loss.

research Finasteride in the Treatment of Men with Frontal Male Pattern Hair Loss

187 citations , June 1999 in “Journal of The American Academy of Dermatology”

Finasteride effectively treats frontal hair loss with few side effects.

research Finasteride in the Treatment of Men with Androgenetic Alopecia

581 citations , October 1998 in “Journal of The American Academy of Dermatology”

Finasteride safely and effectively treats male pattern hair loss, but may cause reversible sexual issues and harm male fetuses.

research Hair Regrowth

118 citations , April 1998 in “Dermatologic Clinics”

Finasteride and minoxidil are effective for hair regrowth, while treatments for alopecia areata have varying success and continuous treatment is necessary.

Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia

research Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia

416 citations , September 1997 in “Journal of Investigative Dermatology”

People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.

research Whole Hair Follicle Culture

57 citations , October 1996 in “Dermatologic clinics”

HA-MNs with MXD effectively treat hair loss better than topical MXD with fewer side effects.

research Androgen Metabolism as It Affects Hair Growth in Androgenetic Alopecia

143 citations , October 1996 in “Dermatologic Clinics”

Too much androgen can cause hair loss; finasteride may help.

research Chronic Telogen Effluvium

75 citations , October 1996 in “Dermatologic Clinics”

Chronic Telogen Effluvium is a hair loss condition in middle-aged women that usually doesn't lead to complete baldness.

research Treatment of Alopecia Areata

48 citations , October 1996 in “Dermatologic clinics”

Some treatments can help with hair regrowth in alopecia areata, but results vary and long-term use is often needed without changing the disease's outcome.

research Guidelines of Care for Androgenetic Alopecia

37 citations , September 1996 in “Journal of The American Academy of Dermatology”

Treat genetic hair loss early with FDA-approved medications and consider hair transplantation.

research Allergic Contact Dermatitis from Minoxidil

32 citations , May 1995 in “Contact Dermatitis”

Minoxidil can cause allergic reactions, but testing helps identify the cause.

research Androgenetic Alopecia: An Autosomal Dominant Disorder

80 citations , January 1995 in “The American Journal of Medicine”

Hair loss in androgenetic alopecia is caused by genetic factors and androgen excess, and can be treated with combined therapies.

The Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Scalp Skin Testosterone and Dihydrotestosterone Concentrations in Patients with Male Pattern Baldness

research The Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Scalp Skin Testosterone and Dihydrotestosterone Concentrations in Patients with Male Pattern Baldness

59 citations , September 1994 in “The Journal of Clinical Endocrinology and Metabolism”

Finasteride reduces scalp DHT levels, potentially treating male pattern baldness.

research Androgenetic Alopecia in the Female

82 citations , March 1994 in “Archives of Dermatology”

2% topical minoxidil effectively treats female hair loss with minimal side effects.

research Disorders of Hair Growth: Diagnosis and Treatment

26 citations , January 1994 in “McGraw-Hill eBooks”

Many hair loss conditions can be treated.

research Psychological Effects of Androgenetic Alopecia on Women: Comparisons with Balding Men and Female Control Subjects

222 citations , October 1993 in “Journal of The American Academy of Dermatology”

Hair loss affects women's mental health more than men's, causing anxiety, low self-esteem, and social insecurity.

research Use of Topical Minoxidil Therapy for Androgenetic Alopecia in Women

58 citations , October 1993 in “International Journal of Dermatology”

Minoxidil helps hair growth and reduces shedding in women.

research Diagnostic and Predictive Value of Horizontal Sections of Scalp Biopsy Specimens in Male Pattern Androgenetic Alopecia

309 citations , May 1993 in “Journal of The American Academy of Dermatology”

Horizontal scalp biopsy sections effectively diagnose and predict MPAA, with follicular density and inflammation impacting hair regrowth.

research Telogen Effluvium: A Comprehensive Review

214 citations , March 1993 in “Archives of Dermatology”

Telogen effluvium is a reversible hair loss condition that requires a detailed diagnosis and often resolves on its own.

research Systemic Steroids With or Without 2% Topical Minoxidil in the Treatment of Alopecia Areata

101 citations , November 1992 in “Archives of Dermatology”

Steroids help hair regrowth, and minoxidil slows post-steroid hair loss, but effects are temporary.

research The Effect of Finasteride in Men with Benign Prostatic Hyperplasia

1040 citations , October 1992 in “The New England Journal of Medicine”

Finasteride effectively treats BPH but may increase sexual dysfunction risk.

research Topical Minoxidil in Alopecia Areata: No Effect on the Perifollicular Lymphoid Infiltration

33 citations , July 1992 in “Journal of Investigative Dermatology”

Minoxidil doesn't affect perifollicular lymphoid infiltration in alopecia areata patients.

research The Psychological Effects of Androgenetic Alopecia in Men

192 citations , June 1992 in “Journal of The American Academy of Dermatology”

Hair loss can cause low self-esteem, anxiety, and depression in men.

Hair Growth Effects of Oral Administration of Finasteride, a Steroid 5 Alpha-Reductase Inhibitor, Alone and in Combination with Topical Minoxidil in the Balding Stumptail Macaque

research Hair Growth Effects of Oral Administration of Finasteride, a Steroid 5 Alpha-Reductase Inhibitor, Alone and in Combination with Topical Minoxidil in the Balding Stumptail Macaque

34 citations , February 1992 in “The Journal of Clinical Endocrinology and Metabolism”

Finasteride and minoxidil together promote hair growth better than either alone.

research Androgens and the Hair Follicle: Cultured Human Dermal Papilla Cells as a Model System

22 citations , December 1991 in “PubMed”

research Alopecia Areata in Children: Response to Treatment with Diphencyprone

84 citations , August 1991 in “British Journal of Dermatology”

Most children treated with diphencyprone regrew some or all of their hair.

research Contact Dermatitis in Reaction to 2% Topical Minoxidil Solution

23 citations , April 1991 in “Journal of The American Academy of Dermatology”

Minoxidil solution can cause skin irritation and allergies in some users.

research Quantitative Estimation of Hair Growth: Androgenetic Alopecia in Women and the Effect of Minoxidil

85 citations , December 1990 in “Journal of Investigative Dermatology”

Minoxidil promotes hair growth in women with early-stage alopecia.

research The Clinical Development of a 5α-Reductase Inhibitor, Finasteride

211 citations , November 1990 in “The Journal of Steroid Biochemistry and Molecular Biology”

Finasteride effectively treats BPH, but needs more trials to understand potential.

research Five-Year Follow-Up of Men with Androgenetic Alopecia Treated with Topical Minoxidil

70 citations , April 1990 in “Journal of The American Academy of Dermatology”

Minoxidil treatment increased hair growth for up to 5 years, requiring twice daily application.

research Minoxidil Stimulates Mouse Vibrissae Follicles in Organ Culture

121 citations , March 1989 in “Journal of Investigative Dermatology”

Minoxidil can help grow hair in mice by making cells grow and improving hair quality. More research needed.

research Evaluation of Anthralin in the Treatment of Alopecia Areata

109 citations , November 1987 in “Archives of dermatology”

Anthralin cream helped 25% of patients with severe alopecia areata regrow hair, but caused skin irritation.

research Long-Term Efficacy of Topical Minoxidil in Male Pattern Baldness

41 citations , March 1987 in “Journal of The American Academy of Dermatology”

Topical minoxidil effectively treats male pattern baldness and prevents hair loss.

research Topical Minoxidil Solution (1% and 5%) in the Treatment of Alopecia Areata

101 citations , March 1987 in “Journal of The American Academy of Dermatology”

Minoxidil solution helps hair regrowth in alopecia areata, with 5% being more effective.

research Safety and Efficacy of Topical Minoxidil in the Management of Androgenetic Alopecia

67 citations , March 1987 in “Journal of The American Academy of Dermatology”

Minoxidil helps hair growth and prevents hair loss in androgenetic alopecia. It's safe and effective.

research Topical Minoxidil (3%) in Extensive Alopecia Areata, Including Long-Term Efficacy

54 citations , March 1987 in “Journal of The American Academy of Dermatology”

3% topical minoxidil effectively treats extensive alopecia areata with few side effects.

research Effect of Minoxidil on Pre- and Postconfluent Keratinocytes

22 citations , March 1987 in “Journal of The American Academy of Dermatology”

Minoxidil prolongs cell life, slows aging, and may produce longer hairs.

research Topical Minoxidil in Early Androgenetic Alopecia

44 citations , March 1987 in “Journal of The American Academy of Dermatology”

Using minoxidil on balding scalps can stimulate hair regrowth and increase blood flow. It's an effective treatment for early hair loss.

research Topical Minoxidil in Extensive Alopecia Areata, Including 3-Year Follow-Up

34 citations , January 1987 in “Dermatology”

Topical minoxidil effectively and safely treats extensive alopecia areata but doesn't change its course.

research Biology of Hair Growth

46 citations , May 1986 in “Seminars in Reproductive Medicine”

Testosterone and dihydrotestosterone affect hair growth, and new techniques like the folliculogram help study it, but fully understanding hair growth is still complex.

research Topical Minoxidil Dose-Response Effect in Alopecia Areata

54 citations , February 1986 in “Archives of Dermatology”

Higher minoxidil concentration (5%) works better for severe hair loss, with most patients seeing regrowth in 48-60 weeks.

research Contact Dermatitis to Minoxidil

34 citations , September 1985 in “Contact Dermatitis”

Minoxidil can cause skin irritation like eczema and rash in some users.

research Cyclic Dynamics of Hair Follicles and the Effect of Minoxidil on the Bald Scalps of Stumptailed Macaques

54 citations , June 1985 in “American Journal of Dermatopathology”

Minoxidil helps grow longer, thicker hair in bald scalps of stumptailed macaques, and early treatment is more effective.

research The Effects of Two Doses of Spironolactone on Serum Androgens and Anagen Hair in Hirsute Women

142 citations , February 1985 in “Fertility and sterility”

Spironolactone reduced hair thickness and some testosterone levels in women with excessive hair growth.

research The inheritance of common baldness: Two B or not two B ?

203 citations , November 1984 in “Journal of the American Academy of Dermatology”

Common baldness is likely inherited through multiple genes, not just one.

research Classification of the Types of Androgenetic Alopecia (Common Baldness) Occurring in the Female Sex

666 citations , September 1977 in “British Journal of Dermatology”

Common baldness, also known as Androgenetic Alopecia, is caused by a combination of genetic factors and hormones called androgens.

Testosterone Metabolism in the Skin: A Review of Its Function in Androgenetic Alopecia, Acne Vulgaris, and Idiopathic Hirsutism Including Recent Studies with Antiandrogens

research Testosterone Metabolism in the Skin: A Review of Its Function in Androgenetic Alopecia, Acne Vulgaris, and Idiopathic Hirsutism Including Recent Studies with Antiandrogens

43 citations , November 1975 in “Archives of Dermatology”

Testosterone affects hair loss, acne, and excessive hair growth, and antiandrogens can help treat these conditions.

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19 / 19 results

research Review of Oral Minoxidil as Treatment of Hair Disorders: In Search of the Perfect Dose

21 citations , March 2021

Oral minoxidil effectively treats hair loss, with women needing lower doses (0.25 to 2.5 mg daily) and men needing higher doses (1.25 to 5 mg daily).

research Childhood Alopecia Areata: An Overview of Treatment and Recent Patents

5 citations , July 2020 in “Recent patents on inflammation & allergy drug discovery”

Childhood Alopecia Areata causes hair loss and requires varied treatments, with psychological support being crucial.

research Alopecia and Hair Damage Induced by Oncological Therapy

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research Most Common Patient Hair Questions And Answers

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research The Influence of Methotrexate on Hair Loss While Using Immunomodulatory Doses

February 2019 in “PubMed”

Methotrexate treatment often causes hair loss.

research Advanced Approaches in Alopecia

4 citations , June 2017 in “Pharmaceutical and Biological Evaluations”

New methods for treating hair loss are being developed.

research Hair Loss in Women: Diagnosis and Management of Nonscarring Diffuse Alopecias

11 citations , December 2014 in “Clinical Obstetrics and Gynecology”

Obstetrician/gynecologists can diagnose and manage female hair loss with careful history taking and examination.

research Plants as Potential Active Components in Treatment of Androgenetic Alopecia

6 citations , March 2014 in “Herba Polonica”

Plant extracts may help treat hormone-related hair loss.

research Hair Diseases: Alopecia Areata and Androgenetic Alopecia

January 2010

Alopecia areata, a type of hair loss, may be passed through T cells and has genetic links, while treatments vary in effectiveness. Male pattern baldness can be treated with finasteride and is influenced by androgens in hair follicles.

research Investigational Medications in the Treatment of Alopecia

3 citations , February 2005 in “Expert Opinion on Investigational Drugs”

New treatments for hair loss are being developed using molecular biology.

research Common Hair Loss Disorders

29 citations , July 2003 in “PubMed”

Hair loss affects both genders and can impact well-being, with treatments available for various types.

research Alopecia in Women: A 2003 Review

18 citations , March 2003 in “PubMed”

Hair loss in women can be due to abnormal hair growth cycles or damaged hair follicles, with the most common type being androgenetic alopecia; treatment varies by cause, and the psychological impact is significant.

research Causes of Hair Loss and Developments in Hair Rejuvenation

69 citations , February 2002 in “International Journal of Cosmetic Science”

Some hair loss can be treated, especially in women due to nutrition, but some types remain untreatable.

research Advances in the Treatment of Male Androgenetic Alopecia: A Brief Review of Finasteride Studies

10 citations , June 2001 in “PubMed”

Finasteride is effective in growing hair and stopping hair loss in men with mild to moderate alopecia.

research Treatments for Androgenetic Alopecia and Alopecia Areata

72 citations , January 2001 in “Drugs”

Minoxidil and finasteride treat hair loss; more research needed for other options.

research Drug-Induced Hair Loss and Hair Growth

147 citations , April 1994 in “Drug Safety”

Some drugs can cause hair loss or increase hair growth, but these effects are usually reversible when the drug is stopped.

Chapter 20: Pathogenesis and Treatment of Alopecias