Distinctive T Cell Patterns Defining Lymphocytic Alopecia and Alternate Autoimmune and Stem Cell Pathways, Linked to Pleiotropic Functions of Regulatory T Cells Within iSALT

    June 2026 in “ American Journal of Dermatopathology ”
    Steven Kossard
    Studysummary This review describes various T-cell-mediated alopecias characterized by distinct lymphocytic patterns and explores their pathophysiology. It highlights the role of CD8+ and regulatory T cells, the JAK/STAT pathway, and stem cell niches, contributing to understanding and potentially addressing these hair loss conditions.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on doi.org →
    Discuss this study in the Community →

    Research cited in this study 26

    1. Sebaceous Gland Atrophy Due to Seborrheic Dermatitis in a Patient with Alopecia: A Potential Pitfall Journal of cutaneous pathology · 2024
    2. A Cross-Sectional Observational Study Showing Sebaceous Glands Differences Between Psoriatic Alopecia and Alopecia Areata JAAD International · 2024
    3. Deciphering the Molecular Mechanisms of Stem Cell Dynamics in Hair Follicle Regeneration 2024
    4. The Potential of Regulatory T Cell-Based Therapies for Alopecia Areata Frontiers in Immunology · 2023
    5. Involvement of ILC1-Like Innate Lymphocytes in Human Autoimmunity: Lessons from Alopecia Areata eLife · 2023
    6. Integrative and Mechanistic Approach to the Hair Growth Cycle and Hair Loss Journal of Clinical Medicine · 2023
    7. An Overview of JAK/STAT Pathways and JAK Inhibition in Alopecia Areata Frontiers in immunology · 2022
    8. Alopecia Areata: An Update on Etiopathogenesis, Diagnosis, and Management Clinical Reviews in Allergy & Immunology · 2021
    9. Alopecia Areata: A Review on Diagnosis, Immunological Etiopathogenesis, and Treatment Options Clinical and Experimental Medicine · 2021
    10. Hair Follicle Immune Privilege and Its Collapse in Alopecia Areata Experimental dermatology · 2020
    11. Fibrosing Alopecia in a Pattern Distribution Journal of The American Academy of Dermatology · 2020
    12. The Mesenchymal Niche of the Hair Follicle Induces Regeneration by Releasing Primed Progenitors from Inhibitory Effects of Quiescent Stem Cells Cell Reports · 2018
    13. Hair Follicle Immune Privilege Revisited: The Key to Alopecia Areata Management ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2017
    14. Regulatory T Cells in Skin: Role of Foxp3+ CD4+ Tregs in Skin Homeostasis and Immune Tolerance Immunology · 2017
    15. Frontal Fibrosing Alopecia: Reflections and Hypotheses on Etiology and Pathogenesis Experimental dermatology · 2016
    16. STAT5 Activation in the Dermal Papilla Is Important for Hair Follicle Growth Phase Induction Journal of Investigative Dermatology · 2016
    17. Pathologic Diagnosis of Central Centrifugal Cicatricial Alopecia on Horizontal Sections American Journal of Dermatopathology · 2014
    18. Lichen Planopilaris Is Characterized By Immune Privilege Collapse Of The Hair Follicle's Epithelial Stem Cell Niche The Journal of Pathology · 2013
    19. Frontal Fibrosing Alopecia: A Review of 60 Cases Journal of The American Academy of Dermatology · 2012
    20. Central Centrifugal Cicatricial Alopecia Dermatologic Therapy · 2008
    21. Female Pattern Hair Loss and Its Relationship to Permanent/Cicatricial Alopecia: A New Perspective Journal of Investigative Dermatology Symposium Proceedings · 2005
    22. Lupus Panniculitis Clinically Simulating Alopecia Areata Australasian Journal of Dermatology · 2002
    23. Diffuse Alopecia With Stem Cell Folliculitis American Journal of Dermatopathology · 1999
    24. Postmenopausal Frontal Fibrosing Alopecia: A Frontal Variant of Lichen Planopilaris Journal of the American Academy of Dermatology · 1997
    25. Postmenopausal Frontal Fibrosing Alopecia Archives of Dermatology · 1994
    26. Alopecia Mucinosa: A Series of Cases Over Seven Years A M A Archives of Dermatology · 1957