Diffuse Alopecia With Stem Cell Folliculitis

    February 1999 in “ American Journal of Dermatopathology ”
    Steven Kossard
    TLDR Lymphocytes may hinder hair stem cells, causing hair loss without scarring.
    A 34-year-old woman experienced an 8-year history of slowly progressive diffuse nonscarring alopecia with reduced hair density. Scalp biopsies revealed increased miniaturized follicles and a distinctive lymphocytic infiltrate in the stem cell-rich regions, suggesting a possible stem cell folliculitis. This pattern was similar to reactions seen in graft versus host disease and androgenetic alopecia. The presence of peribulbar lymphocytic inflammation suggested a variant of alopecia areata. The findings indicated that lymphocytes might inhibit stem cell function without destroying them, prompting a reconsideration of cases classified as chronic diffuse alopecia areata.
    Discuss this study in the Community →

    Research cited in this study

    7 / 7 results

    Related Community Posts Join

    6 / 1000+ results
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      by nkrata in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community The Worst Hair Loss Condition You (MAY) have: LPP

      in Research/Science  52 upvotes 1 year ago
      Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

      community DHT Harms Scalp Microbiome: DHT Itch is REAL

      in Research/Science  414 upvotes 11 months ago
      Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.

      community To all the young non-responders out there

      in Update  120 upvotes 3 years ago
      A 21 year old who has been taking various treatments for hair loss such as dutasteride, RU58841, minoxidil and finasteride with no results. Other users share their experiences of dealing with hair loss at an early age and offer advice on how to cope.

      community Venting My Frustration with Doctors

      in Chat  14 upvotes 1 year ago
      A 22.5-year-old male is frustrated with doctors for not taking his diffuse thinning seriously. He has been using finasteride for 2.5 years, avoids topical minoxidil due to dandruff, and is hesitant about oral minoxidil due to weight and injury concerns.

    Related Research

    3 / 3 results