Inducible Skin-Associated Lymphoid Tissue (iSALT) Detected in Scalp Treated with Topical Immunotherapy for Alopecia Areata

May 2017 in “ The journal of investigative dermatology/Journal of investigative dermatology ”

Yohei Natsuaki, Norito Ishii, Chika Ohata, Kenji Kabashima, Takekuni Nakama

inducible skin-associated lymphoid tissue iSALT alopecia areata topical immunotherapy T cells B cells dendritic cells dermal perivascular areas hair bulge chronic delayed-type hypersensitivity responses AA

TLDR Topical immunotherapy for alopecia areata may work by creating immune cell clusters in the skin.

The study investigated the presence of inducible skin-associated lymphoid tissue (iSALT) in the scalp of patients with alopecia areata (AA) undergoing topical immunotherapy. Immunohistochemistry on skin sections from these patients revealed tightly packed infiltrations of T cells, B cells, and dendritic cells (DCs) in the dermal perivascular areas and around the hair bulge. These findings suggested that iSALT might play a crucial role in the effectiveness of topical immunotherapy for AA by facilitating chronic delayed-type hypersensitivity responses.

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