Effect of a Sphingolipid-Mimetic Compound on Hair Growth Promotion: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

November 2019 in “ Journal of Cosmetic Dermatology ”

Weon Ju Lee, Chihyeon Sohng, Jun Young Kim, Kyung Duck Park, Yong Hyun Jang, Seok‐Jong Lee

sphingolipid-mimetic compound bis-oleamide isopropyl alcohol BOI pattern hair loss ceramide HS

Studysummary This study found that applying a 1% BOI lotion improved hair density and thickness in patients with mild pattern hair loss over six months. Our plain-language summary of this paper — not a Tressless recommendation.

The study investigated the effects of a sphingolipid-mimetic compound, specifically bis-oleamide isopropyl alcohol (BOI), on hair growth in 58 patients with mild pattern hair loss. Conducted as a randomized, double-blind, placebo-controlled clinical trial over 6 months, participants in the experimental group applied 1% BOI lotion daily. Results showed a decrease in daily hair loss from 52.52 to 40.41 hairs, an increase in vertex hair density from 131.07 to 156.00, and an increase in frontal hair density from 104.21 to 124.10. Additionally, hair thickness and growth rate improved, suggesting that ceramide HS could be a promising treatment for pattern hair loss.

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