Regenerative Medicine Applications in Dermatology and Aesthetics

June 2022 in “ Cosmoderma ”

Hitaishi Mehta, Anuradha Bishnoi, Sunil Dogra

regenerative medicine hair restoration platelet-rich plasma PRP stem cells growth factors exosomes adipose-derived stem cells ADSCs microneedling fractional carbon dioxide laser cellular replication differentiation apoptosis fractional CO2 laser

From the encyclopedia

Platelet-Rich Plasma →

growth factors taken from your blood and injected into your scalp to stimulate hair

Exosomes →

Microscopic delivery system that sends growth-promoting signals to hair follicles

Microneedling →

technique to create small wounds in skin to activate collagen production and hair growth

Studysummary This review discusses regenerative medicine's applications in dermatology, highlighting the need for quality clinical trials to optimize treatments like PRP, stem cells, and exosomes, and reports no new results. Our plain-language summary of this paper — not a Tressless recommendation.

Regenerative medicine, which aims to restore damaged tissues, has applications in dermatology such as wound healing, hair restoration, and skin rejuvenation. The most common treatments are platelet-rich plasma (PRP), stem cells, growth factors, and exosomes, but they lack high-quality evidence supporting their use. A study of 71 patients showed significant improvement in hair density with low dose adipose-derived stem cells (ADSCs). A meta-analysis of 17 trials showed a significant increase in hair density with PRP therapy. PRP has also been used with microneedling and fractional carbon dioxide laser for acne scarring, but evidence is limited. Exosomes have potential roles in hair restoration, skin rejuvenation, scar repair, and skin pigmentation. They modulate cellular replication, differentiation, and apoptosis. However, there are challenges such as lack of standardization in isolation, production, yield, and identification. The document concludes that regenerative medicine will play an important role in aesthetics, but more research is needed.

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Research cited in this study

20 / 20 results

research Effectiveness of Platelet-Rich Plasma Therapy in Androgenic Alopecia: A Meta-Analysis

7 citations , February 2022 in “Journal of Personalized Medicine”

This meta-analysis found that platelet-rich plasma treatments significantly increased hair density in patients with androgenic alopecia, with results influenced by treatment frequency and patient age.

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5 citations , January 2021 in “Journal of Cosmetic Dermatology”

This study found that adding platelet-rich plasma with microneedling to conventional medical treatment significantly increased hair density and diameter in androgenetic alopecia patients compared to medical treatment alone.

Comparative Evaluation of the Clinical Efficacy of PRP Therapy, Minoxidil, and Their Combination with Immunohistochemical Study of the Dynamics of Cell Proliferation in the Treatment of Men with Androgenetic Alopecia

research Comparative Evaluation of the Clinical Efficacy of PRP Therapy, Minoxidil, and Their Combination with Immunohistochemical Study of the Dynamics of Cell Proliferation in the Treatment of Men with Androgenetic Alopecia

13 citations , September 2020 in “International Journal of Molecular Sciences”

This study found that combining platelet-rich plasma therapy with minoxidil was more effective in treating androgenetic alopecia in men than either treatment alone.

A Randomized, Double-Blind, Vehicle-Controlled Clinical Study of Hair Regeneration Using Adipose-Derived Stem Cell Constituent Extract in Androgenetic Alopecia

research A Randomized, Double-Blind, Vehicle-Controlled Clinical Study of Hair Regeneration Using Adipose-Derived Stem Cell Constituent Extract in Androgenetic Alopecia

25 citations , May 2020 in “Stem Cells Translational Medicine”

In this randomized clinical trial, the authors reported that adipose-derived stem cell constituent extract topical solution increased hair density and thickness in patients with androgenetic alopecia over 16 weeks compared to placebo.

research Cell-Enriched Autologous Fat Grafts to Follicular Niche Improves Hair Regrowth in Early Androgenetic Alopecia

8 citations , February 2020 in “Aesthetic Surgery Journal”

This study found that early male hair loss treatment with Puregraft fat and low-dose adipose-derived regenerative cells increased terminal hair counts at 24 weeks compared to a saline control, indicating promise for androgenetic alopecia treatment.

research Autologous Micrografts from Scalp Tissue: Trichoscopic and Long-Term Clinical Evaluation in Male and Female Androgenetic Alopecia

41 citations , January 2020 in “BioMed Research International”

This study found that micrografts containing human hair follicle mesenchymal stem cells significantly increased hair count and density compared to placebo over 58 weeks in patients experiencing hair loss.

research Comparison of Efficacy of Platelet-Rich Plasma Therapy With or Without Topical 5% Minoxidil in Male-Type Baldness: A Randomized, Double-Blind Placebo Control Trial

26 citations , December 2019 in “Indian Journal of Dermatology, Venereology and Leprology”

This study found that platelet-rich plasma combined with topical minoxidil was more effective in increasing hair density for male-type baldness than either treatment alone.

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60 citations , June 2019 in “Ageing Research Reviews”

This review discusses the potential of adipose-derived tissue components like nanofat and stem cells for aesthetic rejuvenation, covering their use in hair growth, scar reduction, and more, without reporting new clinical results.

research A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth

192 citations , April 2019 in “ACS nano”

In a mouse model, this study demonstrated that a microneedle patch system using keratin and integrated with MSC-derived exosomes and UK5099 promoted hair regrowth more efficiently than traditional delivery methods.

Exosomes Derived from Human Dermal Papilla Cells Promote Hair Growth in Cultured Human Hair Follicles and Augment the Hair-Inductive Capacity of Cultured Dermal Papilla Spheres

research Exosomes Derived from Human Dermal Papilla Cells Promote Hair Growth in Cultured Human Hair Follicles and Augment the Hair-Inductive Capacity of Cultured Dermal Papilla Spheres

58 citations , March 2019 in “Experimental Dermatology”

This study suggests that exosomes derived from dermal papilla cells, especially those cultured in three dimensions, promote hair growth and regeneration by enhancing follicular cell activity.

research Suppression of Wnt/β-Catenin Signaling by EGF Receptor Is Required for Hair Follicle Development

25 citations , September 2018 in “Molecular Biology of the Cell”

This study found that in mice lacking EGFR, elevated Wnt signaling disrupts hair follicle development by affecting cell proliferation and differentiation, revealing a critical role for EGFR in regulating these processes.

research Regulation of Hair Follicle Development by Exosomes Derived from Dermal Papilla Cells

87 citations , April 2018 in “Biochemical and Biophysical Research Communications”

In this study, dermal papilla cell-derived exosomes accelerated hair follicle growth in mice, suggesting potential for treating hair loss by modulating key signaling pathways.

research Hair Follicle Growth by Stromal Vascular Fraction-Enhanced Adipose Transplantation in Baldness

30 citations , July 2017 in “Stem cells and cloning”

This study found that scalp injection of fat enriched with stem cells may offer a promising alternative for treating early genetic alopecia in both men and women.

Platelet-Rich Plasma in Combination With 5% Minoxidil Topical Solution and 1 mg Oral Finasteride for the Treatment of Androgenetic Alopecia: A Randomized Placebo-Controlled, Double-Blind, Half-Head Study

research Platelet-Rich Plasma in Combination With 5% Minoxidil Topical Solution and 1 mg Oral Finasteride for the Treatment of Androgenetic Alopecia: A Randomized Placebo-Controlled, Double-Blind, Half-Head Study

19 citations , May 2017 in “Dermatologic Surgery”

Combining platelet-rich plasma with 5% minoxidil solution improves hair regrowth in androgenetic alopecia patients.

research Hair Regeneration Therapy: Application of Adipose-Derived Stem Cells

55 citations , May 2017 in “Current stem cell research & therapy”

In this study, Japanese patients treated with adipose-derived stem cell-conditioned medium for hair regeneration showed positive outcomes, suggesting it may be an effective new therapy for alopecia.

research Stem Cell Therapy as a Novel Therapeutic Intervention for Resistant Cases of Alopecia Areata and Androgenetic Alopecia

39 citations , August 2016 in “Journal of Dermatological Treatment”

This study observed that autologous bone marrow derived mononuclear cells and follicular stem cells were both safe and effective for improving resistant alopecia areata and androgenetic alopecia, with no serious adverse events.

Combined Autologous Platelet-Rich Plasma with Microneedling Versus Microneedling with Distilled Water in the Treatment of Atrophic Acne Scars: A Concurrent Split-Face Study

research Combined Autologous Platelet-Rich Plasma with Microneedling Versus Microneedling with Distilled Water in the Treatment of Atrophic Acne Scars: A Concurrent Split-Face Study

106 citations , January 2016 in “Journal of Cosmetic Dermatology”

This study found that adding platelet-rich plasma to microneedling improved outcomes for atrophic acne scars more than microneedling alone, according to both quantitative and qualitative assessments.

research Fibroblast Growth Factors Stimulate Hair Growth Through Beta-Catenin and Shh Expression in C57BL/6 Mice

64 citations , January 2015 in “BioMed Research International”

In this study, topical application of fibroblast growth factors was found to promote hair growth by inducing and prolonging the anagen phase in telogenic C57BL/6 mice, suggesting potential as hair growth-promoting agents.

research Hair Growth Promoting Effects of Adipose Tissue-Derived Stem Cells

81 citations , December 2009 in “Journal of Dermatological Science”

This review discusses the paracrine effects of adipose tissue-derived stem cells on surrounding cells and tissues, noting their potential therapeutic benefits, but reports no new clinical results.

research Androgen Induction of Follicular Epithelial Cell Growth Is Mediated via Insulin-like Growth Factor-I from Dermal Papilla Cells

173 citations , July 1995 in “Biochemical and biophysical research communications”

This study suggests that IGF-I may mediate androgen-induced hair growth in outer root sheath cells cocultured with beard dermal papilla cells.