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    Thyroid Hormone Receptor Agonist Promotes Hair Growth in Mice

    February 2022 in “ Clinical, Cosmetic and Investigational Dermatology ”
    Peiqiu Zhu, Wei‐Wei Deng, Jin Yü, Shuxia Yang
    Studysummary In this study, researchers found that the thyroxine receptor agonist TDM10842 accelerated the onset of anagen, a hair growth phase, in C3H mice, potentially through activation of the Wnt/beta-catenin and Hedgehog pathways, with Pclaf playing a key role in this process.
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    Research cited in this study 13

    1. Hes1 Regulates Anagen Initiation and Hair Follicle Regeneration Through Modulation of Hedgehog Signaling Stem Cells · 2019
    2. Deciphering the Molecular Morphology of the Human Hair Cycle: Wnt Signalling During the Telogen–Anagen Transformation British Journal of Dermatology · 2019
    3. Hedgehog Stimulates Hair Follicle Neogenesis by Creating Inductive Dermis During Murine Skin Wound Healing Nature Communications · 2018
    4. Dermatologic Manifestations of Endocrine Disorders Translational pediatrics · 2017
    5. Hair Follicle Stem Cell Proliferation, Akt and Wnt Signaling Activation in TPA-Induced Hair Regeneration Histochemistry and Cell Biology · 2017
    6. The Thyroid Hormone Analogue KB2115 (Eprotirome) Prolongs Human Hair Growth (Anagen) Ex Vivo Journal of Investigative Dermatology · 2016
    7. Impaired Hair Growth and Wound Healing in Mice Lacking Thyroid Hormone Receptors PloS one · 2014
    8. Signaling Involved in Hair Follicle Morphogenesis and Development International Journal of Molecular Sciences · 2014
    9. A Matter of Life and Death: Self-Renewal in Stem Cells EMBO Reports · 2012
    10. Exploring the Thyroid-Skin Connection: Concepts, Questions, and Clinical Relevance Journal of Investigative Dermatology · 2009
    11. Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation The Journal of Clinical Endocrinology & Metabolism · 2008
    12. Modulation of Hair Growth with Small Molecule Agonists of the Hedgehog Signaling Pathway Journal of Investigative Dermatology · 2005
    13. Thyroid Hormone Receptor β1 Is Expressed in the Human Hair Follicle British journal of dermatology/British journal of dermatology, Supplement · 2000