Selective Blockade of Gamma C Pathway Ameliorates Alopecia Areata in a Humanized Murine Model

    June 2026 in “ Journal of Investigative Dermatology ”
    Wai Chung Wu, Muthu Iswarya Gandhi Sethuraman, Tak Keung Tong … Chin Wai Hui
    Studysummary This study reported that the anti-γc antibody hC2 restored hair follicle homeostasis and suppressed hair loss in an AA-like mouse model by inhibiting autoreactive T-cell activity, suggesting that hC2 may offer a safer and more effective treatment for alopecia areata compared to current Jak inhibitors.
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    Research cited in this study 28

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    8. Using Patient Preference to Inform Ritlecitinib Dose Selection for Alopecia Areata Treatment The Journal of Dermatology · 2025
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    23. Increased Blood Levels of NKG2D+CD4+ T Cells in Patients with Alopecia Areata Journal of the American Academy of Dermatology · 2016
    24. CXCR3 Blockade Inhibits T Cell Migration Into the Skin and Prevents Development of Alopecia Areata Journal of Immunology · 2016
    25. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014
    26. Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity Nature · 2010
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