Possible Involvement of Skin-Resident Memory T Cells in Refractory Chronic Alopecia Areata

    January 2026 in “ Experimental Dermatology ”
    Reiko Kageyama, T. Ito, Kazuo Kurihara … Tetsuya Honda
    Studysummary The study suggests that refractory chronic alopecia areata cases have more infiltrating skin resident memory T cells, and using a JAK inhibitor may be an effective treatment option.
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    Research cited in this study 8

    1. Interleukin-15 Is a Hair Follicle Immune Privilege Guardian Journal of Autoimmunity · 2024
    2. Baricitinib for the Treatment of Alopecia Areata in Adults: Real-World Analysis of 36 Patients Journal of the American Academy of Dermatology · 2024
    3. Inhibition of T-Cell Activity in Alopecia Areata: Recent Developments and New Directions Frontiers in immunology · 2023
    4. Predominant Expression of Interleukin-17 in Chronic Alopecia Areata Compared to IFN-γ in Pathogenic Th17 Cells, Tissue-Resident Memory T Cells and Natural Killer Cells JEADV Clinical Practice · 2023
    5. Vitiligo: An Autoimmune Skin Disease and Its Immunomodulatory Therapeutic Intervention Frontiers in Cell and Developmental Biology · 2021
    6. Resident Memory T Cells in Autoimmune Skin Diseases Frontiers in immunology · 2021
    7. Connective Tissue Sheath of Hair Follicle Is a Major Source of Dermal Type I Procollagen in Human Scalp Journal of dermatological science · 2012
    8. Maintenance of Hair Follicle Immune Privilege Is Linked to Prevention of NK Cell Attack Journal of Investigative Dermatology · 2007