Cholesterol Homeostasis in Hair Follicle Keratinocytes Is Disrupted by Impaired ABCA5 Activity

June 2023 in “ Biochimica and biophysica acta. Molecular and cell biology of lipids ”

Megan A. Palmer, Irundika H.K. Dias, Eleanor Smart, Yvonne Benatzy, Iain S. Haslam

Studysummary In this study, researchers found that knockdown of ABCA5 in primary human hair follicle keratinocytes disrupted cholesterol homeostasis and transportation, suggesting its potential role in hair growth disorders by affecting intracellular cholesterol compartmentalization and LXR-mediated transcriptional activity.

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