PRP for Immune Mediated Alopecias (Alopecia Areata, Alopecia Totalis)

January 2021

Nina Semsarzadeh, Jeffrey S. Dover

platelet-rich plasma stem cells alopecia areata alopecia totalis intralesional corticosteroids topical minoxidil corticosteroids immunosuppressants JAK inhibitors PRP SCs AA

TLDR PRP is effective for treating patchy alopecia areata.

The document reviewed the use of platelet-rich plasma (PRP) and stem cells (SCs) for treating alopecia areata (AA). PRP was found to be as effective as intralesional corticosteroids and topical minoxidil, with potential for a quicker and more sustained response in patchy AA cases. Although stem cells showed promise in preliminary studies, more clinical research was needed to assess their efficacy. The study also addressed the significant psychosocial effects of AA and the inconsistent success rates of current treatments, including corticosteroids, immunosuppressants, and JAK inhibitors.

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Research cited in this study

23 / 23 results

research Successful Treatment of Alopecia Areata Barbae with Platelet-Rich Plasma

6 citations , April 2020 in “Cureus”

Platelet-rich plasma injections can effectively treat alopecia areata barbae.

research Functional Complexity of Hair Follicle Stem Cell Niche and Therapeutic Targeting of Niche Dysfunction for Hair Regeneration

59 citations , March 2020 in “Journal of Biomedical Science”

Understanding how hair follicle stem cells work can help find new ways to prevent hair loss and promote hair growth.

research Harnessing the Power of Regenerative Therapy for Vitiligo and Alopecia Areata

26 citations , June 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

Regenerative therapies show promise for treating vitiligo and alopecia areata.

research The Effect of Platelet-Rich Plasma on Hair Regrowth in Patients with Alopecia Areata Totalis: A Clinical Pilot Study

14 citations , June 2019 in “Dermatologic therapy”

PRP did not significantly regrow hair in alopecia areata totalis patients.

research Platelet-Rich Plasma and Stem Cells for Hair Growth: A Review of the Literature

12 citations , May 2019 in “Aesthetic Surgery Journal”

Platelet-Rich Plasma and stem cell therapy can increase hair count and density, but the best method for preparation and treatment still needs to be determined.

research Evaluation of Platelet-Rich Plasma vs Intralesional Steroid in Treatment of Alopecia Areata

19 citations , May 2019 in “Journal of Cosmetic Dermatology”

Platelet-rich plasma is a safe and effective treatment for hair loss, with fewer relapses than steroid treatment.

research Effects of Mesenchymal Stem Cell Therapy on Alopecia Areata in Cellular and Hair Follicle Organ Culture Models

16 citations , October 2018 in “Experimental Dermatology”

Mesenchymal stem cell therapy may help treat alopecia areata by promoting hair growth and reducing inflammation.

research Cellular Therapy with Human Autologous Adipose-Derived Adult Cells of Stromal Vascular Fraction for Alopecia Areata

45 citations , May 2018 in “Stem Cell Research & Therapy”

Using patients' own fat-derived cells to treat alopecia areata significantly improved hair growth and was safe.

research Alopecia Areata: Treatment Options and Efficacy

182 citations , December 2017 in “Journal of the American Academy of Dermatology”

Some treatments can help with a hair loss condition called alopecia areata, but none ensure lasting results; choices depend on the person, with JAK inhibitors showing promise for severe cases.

research Role of Autologous Platelet-Rich Plasma (PRP) in Limited Alopecia Areata in Local Population

3 citations , November 2016 in “Journal of Pakistan Association of Dermatology”

PRP is a safe and effective treatment for limited alopecia areata.

research Platelet-Rich Plasma Versus Minoxidil 5% in Treatment of Alopecia Areata: A Trichoscopic Evaluation

62 citations , October 2016 in “Dermatologic Therapy”

PRP more effective than minoxidil 5% for treating alopecia areata.

research Stem Cell Therapy as a Novel Therapeutic Intervention for Resistant Cases of Alopecia Areata and Androgenetic Alopecia

39 citations , August 2016 in “Journal of Dermatological Treatment”

Stem cell therapy may help treat tough hair loss cases.

research Platelet-Rich Plasma Combined with Intralesional Triamcinolone Acetonide for the Treatment of Alopecia Areata: A Case Report

15 citations , November 2015 in “Journal of Dermatology and Dermatologic Surgery”

Mixing platelet-rich plasma with triamcinolone acetonide can potentially improve hair regrowth in alopecia areata patients.

research The Effect of Platelet-Rich Plasma in Hair Regrowth: A Randomized Placebo-Controlled Trial

214 citations , September 2015 in “Stem Cells Translational Medicine”

Platelet-rich plasma injections significantly improved hair regrowth and thickness in patients with hair loss.

research Successful Treatment of Corticosteroid-Resistant Ophiasis-Type Alopecia Areata with Platelet-Rich Plasma

30 citations , August 2015 in “JAAD case reports”

Platelet-rich plasma (PRP) injections successfully treated a woman's steroid-resistant hair loss, causing hair to regrow within a month.

research Hair Regrowth in Alopecia Areata Patients Following Stem Cell Educator Therapy

55 citations , April 2015 in “BMC medicine”

Stem Cell Educator therapy helps regrow hair and improve life quality in alopecia areata patients.

research Intralesional Platelet-Rich Plasma vs. Intralesional Triamcinolone in the Treatment of Alopecia Areata: A Comparative Study

15 citations , January 2015 in “International journal of medical research and health sciences”

Platelet rich plasma is as effective as triamcinolone for treating alopecia areata.

research Role of Platelet-Rich Plasma in Chronic Alopecia Areata: Our Centre Experience

61 citations , January 2015 in “Indian Journal of Plastic Surgery”

Platelet-rich plasma treatment could potentially be an effective way to treat chronic alopecia areata with minimal side effects.

research Limited Effectiveness of Platelet-Rich Plasma Treatment on Chronic Severe Alopecia Areata

15 citations , January 2014 in “Hair therapy & transplantation”

Platelet-Rich Plasma treatment has limited and temporary effects on severe Alopecia Areata and does not prevent relapses.

A Randomized, Double-Blind, Placebo- and Active-Controlled, Half-Head Study to Evaluate the Effects of Platelet-Rich Plasma on Alopecia Areata

research A Randomized, Double-Blind, Placebo- and Active-Controlled, Half-Head Study to Evaluate the Effects of Platelet-Rich Plasma on Alopecia Areata

205 citations , April 2013 in “British Journal of Dermatology”

Platelet-rich plasma treatment significantly increased hair regrowth and decreased discomfort in alopecia patients, making it a potentially better and safer treatment option.

Alopecia Areata: An Autoimmune Disease Causing Hair Loss