Pathogenic Variants Affecting Peptidyl Arginine Deiminase 3 and Its Major Substrates Underlie Central Centrifugal Cicatricial Alopecia

    November 2025 in “ Journal of Investigative Dermatology ”
    Noy Keller Rosenthal, Ofer Sarig, Moshe Giladi … Eli Sprecher
    Studysummary This study identified nine pathogenic variants in the PADI3 gene and variants in the S100A3 and TCHH genes in patients with central centrifugal cicatricial alopecia, suggesting a broader genetic basis for the disease and potential targets for genetic testing and therapies.
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    Research cited in this study 16

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