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Did you mean Peptidylarginine Deiminase?

GlossaryPeptidylarginine Deiminase

enzyme converting arginine in proteins to citrulline

Peptidylarginine Deiminase (PAD) is an enzyme that converts arginine residues in proteins into citrulline through a process called deimination or citrullination. This modification can affect protein function and is involved in various physiological processes, including the regulation of gene expression and the formation of hair. Dysregulation of PAD activity has been linked to autoimmune diseases and conditions like alopecia.

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research Central Centrifugal Cicatricial Alopecia Associated With PDL1 Loss and Increased Expression of Caspase 3: A Case Series

2 citations, April 2023 in “American Journal of Dermatopathology”

CCCA may involve the PD1/PDL1 pathway and increased caspase 3, leading to permanent hair loss.

research Uncombable Hair Syndrome and Beyond

January 2022 in “Acta dermatovenerologica Alpina, Pannonica et Adriatica (Tiskana izd.)”

Uncombable hair syndrome causes frizzy hair and can affect the nervous system, eyes, and ears, often co-occurring with other hair, skin, nail, and teeth conditions, and is linked to three specific gene mutations.

research Genetic Susceptibility to Alopecia

5 citations, February 2019 in “The New England Journal of Medicine”

Certain mutations in the PADI3 gene may increase the risk of developing a type of scarring hair loss common in women of African descent.

research Characteristic Localization of Neuronatin in Rat Testis, Hair Follicle, Tongue, and Pancreas

2 citations, March 2019 in “Journal of Histochemistry and Cytochemistry”

Neuronatin is found in specific cells within rat testis, hair follicles, tongue, and pancreas, suggesting it has various roles in tissue development and function.

research A Hairy Situation: PADIs in Regeneration and Alopecia

5 citations, December 2021 in “Frontiers in Cell and Developmental Biology”

Enzymes called PADIs play a key role in hair growth and loss.

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