H3K4me3 Regulates the Transcription of RSPO3 in Dermal Papilla Cells to Influence Hair Follicle Morphogenesis and Development

    August 2025 in “ Epigenetics & Chromatin ”
    Zhenyu Zhong, Kangbo Bai, Zhihao Song, Mengxue Yang, Minghao Li, Shanhe Wang, Xin Wang
    Studysummary This study explored the role of the histone modification H3K4me3 in cashmere goat dermal papilla cells, finding that increased levels enhanced cell proliferation and activated Wnt signaling genes, suggesting H3K4me3's involvement in hair follicle development through regulation of the gene RSPO3. Our plain-language summary of this paper — not a Tressless recommendation.
    This study investigates the role of H3K4me3, a key histone modification, in the development of hair follicles, specifically focusing on dermal papilla cells (DPCs) in cashmere goats. Using CUT&Tag technology, researchers mapped the regulation of H3K4me3 and found that increasing its levels enhanced DPC proliferation and promoted Wnt signaling pathway-related gene expression. The study identified RSPO3 as a differentially expressed gene regulated by H3K4me3, which promotes DPC proliferation, inhibits apoptosis, and boosts Wnt pathway gene expression. These findings highlight the importance of H3K4me3 in regulating RSPO3 transcription, contributing to the understanding of hair follicle morphogenesis and development.
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