GPRC6A-Duox1 Axis Regulates the Hair Cycle Through H2O2 Generation

April 2026 in “ Tissue Engineering and Regenerative Medicine ”

박꽃나라, A Cho, Jung Min Park, Mee Sook Jun, Eunbi Ko, Soon‐Sun Bak, Jung Min Suh, Kyoungmi Kim, Young Kwan Sung, Daekee Lee, Yun Soo Bae, Ji Won Oh

GPRC6A Duox1 hair cycle testosterone hydrogen peroxide H2O2 keratinocytes testosterone-mediated hair loss apoptosis anagen phase catagen phase Ki-67 testosterone-induced hair loss hair growth cycle hair loss hair growth hair thinning

Studysummary This study found that the GPRC6A-Duox1 signaling pathway influences hair cycle progression and testosterone-mediated hair loss in mice, suggesting that disruption of this pathway leads to resistance against testosterone-induced hair loss and longer anagen phase duration.

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