Comparison of In Vitro Hair Growth Promotion and Anti-Hair Loss Potential of Thai Rice By-Product from Oryza sativa L. cv. Buebang 3 CMU and Sanpatong

    November 2024 in “ Plants
    Anurak Muangsanguan, Warintorn Ruksiriwanich, Chaiwat Arjin, Sansanee Jamjod, Chanakan Prom‐u‐thai, Pensak Jantrawut, Pornchai Rachtanapun, Patipan Hnorkaew, Apinya Sartsook, Mathukorn Sainakham, Juan Manuel Castagnini, Korawan Sringarm
    This study evaluates the hair growth promotion and anti-hair loss potential of rice bran extracts from Thai rice varieties Buebang 3 CMU and Sanpatong. The ethanolic extract of Buebang 3 CMU (Et-BB3-CMU) showed superior results, with high levels of bioactive compounds like γ-oryzanol and tocopherols, significant antioxidant and anti-inflammatory activities, and enhanced proliferation of human hair follicle dermal papilla cells. It effectively activated hair growth signaling pathways, such as Wnt/β-catenin and Sonic Hedgehog, and suppressed hair loss-related pathways more than standard treatments like minoxidil and finasteride. These findings suggest that Et-BB3-CMU could be a promising natural alternative for hair growth and hair loss prevention.
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