Bioinspired Engineering of Polygonum Multiflorum Root Nanovesicles Regulates Dermal Papilla Cells In Vitro and Stimulates Human Hair Follicle Growth Ex Vivo

    April 2026 in “ Frontiers in Physiology ”
    Ramya Lakshmi Rajendran, Prakash Gangadaran, Mi Hee Kwack … Byeong-Cheol Ahn
    Studysummary This study evaluated nanovesicles derived from Polygonum multiflorum roots, finding that they promote dermal papilla cell proliferation and activate β-catenin signaling, which in turn enhances hair shaft elongation in ex vivo cultured human hair follicles, suggesting their potential use for alopecia treatment.
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    13. Hair Growth Promoting Effects of Emodin in Telogenic C57BL/6 Mice Korean journal of veterinary research · 2016
    14. Hair Growth Promotion Activity and Its Mechanism of Polygonum Multiflorum Evidence-based Complementary and Alternative Medicine · 2015
    15. Topical Application of Polygonum Multiflorum Extract Induces Hair Growth of Resting Hair Follicles Through Upregulating Shh and β-Catenin Expression in C57BL/6 Mice Journal of Ethnopharmacology · 2011
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