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research Topical Application of Polygonum Multiflorum Extract Induces Hair Growth of Resting Hair Follicles Through Upregulating Shh and β-Catenin Expression in C57BL/6 Mice
This study found that Polygonum multiflorum extract may promote hair growth by inducing the anagen phase in the resting hair follicles of mice.
research Acute Hepatitis Due to Shen-Min
This report describes a case of acute liver injury in a woman following the use of Shen-Min, a herbal hair growth supplement, highlighting a potential link to acute hepatitis.
research Topically Used Herbal Products for the Treatment of Hair Loss: Preclinical and Clinical Studies
This review summarizes preclinical and clinical information on herbal products for hair loss treatment, highlighting their mechanisms, follicular penetration, and potential side effects, suggesting they may offer alternatives to synthetic drugs with fewer side effects.
research 5α-Reductase Inhibitory Components as Antiandrogens From Herbal Medicine
This study found that emodin from Polygonum multiflorum showed 5alpha-reductase inhibitory activity, which was more potent than alizarin but less potent than riboflavin.
research Polygonum Multiflorum Extract Supports Hair Growth by Elongating Anagen Phase and Abrogating the Effect of Androgen in Cultured Human Dermal Papilla Cells
This study found that Polygonum multiflorum extract may promote hair growth by increasing anagen duration and activating dermal papilla cells in human hair follicles, as observed in cultured cell models.
research Development Studies of Cuticle Drugs from Natural Resources: Effects of Crude Drug Extracts on Hair Growth in Mice
This study found that Polygonum multiflorum and Panax japonicum extracts could promote hair regrowth in mice, suggesting potential use as hair tonics.
research The Clinical Study Using Oriental Medicine Extract on Male Pattern Hair Loss
This study suggests that a topical oriental medicine extract may improve hair density and scalp condition in individuals experiencing male pattern hair loss after 18 months of use.
research Synergistic Effects of Rhynchosia Nulubilis and Polygonum Multiflorum Extract Combination on Cell Proliferation via Targeting IGFBP-1 and NT-3 and Cytotoxicity Suppression in Testosterone-Induced Human Dermal Papilla Cells
This study found that a 4:1 combination of Rhynchosia nulubilis and Polygonum multiflorum extracts significantly promoted the proliferation of human dermal papilla cells and alleviated testosterone-induced cytotoxicity, suggesting potential for treating hair loss and related disorders through a synergistic approach.
research Latin Cadurcum 'Female Genitals' and Hesychian Greek Xá8veog 'Hog': Is There Any Connection Between the Terms?
This review discusses the bioactive compounds and biological activities of Polygonum multiflorum Thunb. and highlights concerns about its hepatotoxicity, but reports no new clinical results.
research Multi-Target Evaluation of Korean Herbal Compounds Against the SRD5A2 / AR / Beta-Catenin Axis for Androgenetic Alopecia: Boltz-2 Cofold, ChEMBL-Anchored Ranking, ADMET-AI 107-Endpoint Safety Panel, and Pilosebaceous Single-Cell Atlas-Constrained Prioritization of Saponin Re, Emodin, and Biochanin A
This study used a multi-layer in silico framework to evaluate Korean herbal compounds for androgenetic alopecia, identifying Biochanin A, Saponin Re, and Emodin as potential topical candidates with distinct safety and affinity profiles, although these findings remain purely computational without experimental validation.
research Multi-Target Evaluation of Korean Herbal Compounds Against the SRD5A2 / AR / Beta-Catenin Axis for Androgenetic Alopecia: Boltz-2 Cofold, ChEMBL-Anchored Ranking, ADMET-AI 107-Endpoint Safety Panel, and Pilosebaceous Single-Cell Atlas-Constrained Prioritization of Saponin Re, Emodin, and Biochanin A
This study evaluated Korean herbal compounds in silico and identified Biochanin A, Saponin Re, and Emodin as potential topical treatments for androgenetic alopecia, each with specific safety and efficacy considerations.
research Multi-Target Evaluation of Korean Herbal Compounds Against the SRD5A2 / AR / Beta-Catenin Axis for Androgenetic Alopecia: Boltz-2 Cofold, ChEMBL-Anchored Ranking, ADMET-AI 107-Endpoint Safety Panel, and Pilosebaceous Single-Cell Atlas-Constrained Prioritization of Saponin Re, Emodin, and Biochanin A
In this study, in silico analysis identified Saponin Re and Emodin as promising candidates for topical treatment of androgenetic alopecia, with Biochanin A having the most favorable safety profile among the tested compounds.
research Multi-Target Evaluation of Korean Herbal Compounds Against the SRD5A2 / AR / Beta-Catenin Axis for Androgenetic Alopecia: Boltz-2 Cofold, ChEMBL-Anchored Ranking, ADMET-AI 107-Endpoint Safety Panel, and Pilosebaceous Single-Cell Atlas-Constrained Prioritization of Saponin Re, Emodin, and Biochanin A
This study identified Saponin Re and Emodin as top candidates for treating androgenetic alopecia, suggesting future research in dermal papilla cell cultures and scalp organoids despite safety concerns.
research Bioinspired Engineering of Polygonum Multiflorum Root Nanovesicles Regulates Dermal Papilla Cells In Vitro and Stimulates Human Hair Follicle Growth Ex Vivo
This study evaluated nanovesicles derived from Polygonum multiflorum roots, finding that they promote dermal papilla cell proliferation and activate β-catenin signaling, which in turn enhances hair shaft elongation in ex vivo cultured human hair follicles, suggesting their potential use for alopecia treatment.
research Overview of Hair Biology, Research Models, and Evaluation of Hair Regrowth Potential In Vitro and In Vivo
This research explored hair loss and regrowth, highlighting the use of animal models like mice and rats to better understand hair physiology, shedding cycles, and potential treatments, with implications for human application.
research He Shou Wu (Polygonum Multiflorum)-Induced Hepatocellular Hepatitis
This study reports a case linking the use of the herbal supplement He Shou Wu (Polygonum multiflorum) to acute hepatocellular hepatitis, highlighting potential herb-induced liver injury.
research Study on Hair Growth and Scalp Improvement Using Natural Extracts
This review discusses various natural extracts, such as peppermint, rosemary, wild cultivated ginseng, and others, for their potential hair growth promotion effects and calls for further exploration into combinations with fewer side effects.
research Ethnopharmacological Review of Medicinal Plants for the Treatment of Alopecia
This article discusses various synthetic and herbal treatments for alopecia, noting limited effectiveness and associated side effects of synthetic options, and reports no new clinical results.
research Microneedles as the Technique of Drug Delivery Enhancement in Diverse Organs and Tissues
This study reviews the evolution and modifications of microneedle drug delivery systems, initially designed for percutaneous use, now expanded for targeting a variety of tissues and organs such as ocular, oral mucosal, and gastrointestinal, suggesting widespread future applicability.
research The Effects of Negative Pressure by External Tissue Expansion Device on Epithelial Cell Proliferation, Neo-Vascularization, and Hair Growth in a Porcine Model
In a porcine model, this study observed that using an External Tissue Expansion Device increased epidermis thickness, cell proliferation, and vessel density at fat graft recipient sites.