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    Ar/miR-221/IGF-1 Pathway Mediates the Pathogenesis of Androgenetic Alopecia

    January 2022 in “ Social Science Research Network ”
    Kaitao Li, Yan Sun, Shizhao Liu … Yong Miao
    Studysummary This study found that in androgenetic alopecia, the androgen receptor directly increases miR-221 transcription, which suppresses hair growth by targeting IGF-1 and inactivating specific signaling pathways.
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    Research cited in this study 21

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    2. Impairment of Autophagy May Be Associated with Follicular Miniaturization in Androgenetic Alopecia by Inducing Premature Catagen Journal of Dermatology · 2020
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    9. The Effectiveness of Treatments for Androgenetic Alopecia: A Systematic Review and Meta-Analysis Journal of The American Academy of Dermatology · 2017
    10. The Hair Follicle: An Underutilized Source of Cells and Materials for Regenerative Medicine ACS biomaterials science & engineering · 2017
    11. The Androgen Receptor Antagonizes Wnt/β-Catenin Signaling in Epidermal Stem Cells Journal of Investigative Dermatology · 2015
    12. Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type Developmental Cell · 2014
    13. Differential Effects of Caffeine on Hair Shaft Elongation, Matrix and Outer Root Sheath Keratinocyte Proliferation, and Transforming Growth Factor-β2/Insulin-Like Growth Factor-1-Mediated Regulation of the Hair Cycle in Male and Female Human Hair Follicles In Vitro British Journal of Dermatology · 2014
    14. Insulin-Like Growth Factor-1: Roles in Androgenetic Alopecia Experimental Dermatology · 2014
    15. Lichen Planopilaris Is Characterized By Immune Privilege Collapse Of The Hair Follicle's Epithelial Stem Cell Niche The Journal of Pathology · 2013
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    17. Analysis of the MicroRNA Expression Profile of Normal Human Dermal Papilla Cells Treated with 5α-Dihydrotestosterone Molecular Medicine Reports · 2012
    18. Differential Expression Analysis of Balding and Nonbalding Dermal Papilla MicroRNAs in Male Pattern Baldness Using a MicroRNA Amplification Profiling Method British Journal of Dermatology · 2011
    19. Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair Developmental Cell · 2010
    20. The Expression of Insulin-Like Growth Factor 1 in Follicular Dermal Papillae Correlates with Therapeutic Efficacy of Finasteride in Androgenetic Alopecia Journal of The American Academy of Dermatology · 2003
    21. Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia Journal of Investigative Dermatology · 1997