Applications of Mesenchymal Stem Cells in Skin Regeneration and Rejuvenation

This document reviews the therapeutic potential of mesenchymal stem cells (MSCs) for skin regeneration and rejuvenation, noting their ability to enhance cell proliferation, neovascularization, and decrease inflammation, which are crucial for wound healing. MSCs also contribute to collagen production, inhibit metalloproteinase activation, and protect against UV radiation-induced senescence. The review acknowledges the promise of induced pluripotent stem cell (iPSC)-derived MSCs as an advanced option for cell therapy, particularly due to their higher self-renewal and differentiation abilities. It also mentions the role of MSCs in hair regeneration, with MSC-derived extracellular vesicles (EVs) stimulating hair follicle dermal papilla cells and promoting hair regrowth. However, challenges such as the limited availability and proliferative capacity of adult-derived MSCs are noted, with iPSC-derived MSCs (iMSCs) suggested as a promising alternative. The document concludes that further research is needed to understand the molecular mechanisms and ensure safe implementation of MSCs in skin therapy, with iMSCs being a particularly promising area for future clinical applications.