Genetic Interplays Between Msx2 And Foxn1 Are Required For Notch1 Expression And Hair Shaft Differentiation

    December 2008 in “ Developmental Biology ”
    Jing Cai, Jonghyeob Lee, Raphael Kopan, Liang Ma
    Studysummary This study found that the transcription factors Msx2 and Foxn1 are crucial for maintaining Notch1 expression in the hair follicle matrix, which is necessary for proper hair differentiation.
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    Research cited in this study 19

    1. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007
    2. The RAIG Family Member, GPRC5D, Is Associated With Hard-Keratinized Structures ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2004
    3. Defining BMP Functions in the Hair Follicle by Conditional Ablation of BMP Receptor IA The Journal of Cell Biology · 2003
    4. Cyclic Alopecia in Msx2 Mutants: Defects in Hair Cycling and Hair Shaft Differentiation Development · 2002
    5. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    6. Overexpression of Hoxc13 in Differentiating Keratinocytes Results in Downregulation of a Novel Hair Keratin Gene Cluster and Alopecia Development · 2001
    7. A Novel Type II Cytokeratin, mK6irs, Is Expressed in the Huxley and Henle Layers of the Mouse Inner Root Sheath Journal of Investigative Dermatology · 2001
    8. Inhibition of BMP Signaling Affects Growth and Differentiation in the Anagen Hair Follicle The EMBO Journal · 2000
    9. Activation of the Notch Pathway in the Hair Cortex Leads to Aberrant Differentiation of the Adjacent Hair-Shaft Layers Development · 2000
    10. Msx2 Deficiency in Mice Causes Pleiotropic Defects in Bone Growth and Ectodermal Organ Formation Nature genetics · 2000
    11. Whn and mHa3 Are Components of the Genetic Hierarchy Controlling Hair Follicle Differentiation Mechanisms of Development · 1999
    12. Multiple Roles for Activated LEF/TCF Transcription Complexes During Hair Follicle Development and Differentiation Development · 1999
    13. WNT Signaling in the Control of Hair Growth and Structure Developmental biology · 1999
    14. Hoxc13 Mutant Mice Lack External Hair Genes & Development · 1998
    15. Hair Follicle Companion Layer: Reacquainting an Old Friend ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1995
    16. Sequence and Expression of Murine Type I Hair Keratins mHa2 and mHa3 Experimental Cell Research · 1994
    17. Mouse Notch: Expression in Hair Follicles Correlates with Cell Fate Determination ˜The œjournal of cell biology/˜The œJournal of cell biology · 1993
    18. The Secret Life of the Hair Follicle Trends in genetics · 1992
    19. Cultivation of Murine Hair Follicles as Organoids in a Collagen Matrix Journal of Investigative Dermatology · 1987

    Related research 6

    1. Characterization and Expression Analysis of the Hair Keratin Associated Protein KAP26.1 British Journal of Dermatology · 2008
    2. Hair Follicle-Specific Keratins And Their Diseases Experimental cell research · 2007
    3. Keratins of the Human Hair Follicle International review of cytology · 2005
    4. Hair Follicle Differentiation And Regulation The International Journal of Developmental Biology · 2004
    5. Hair Keratin Pattern in Human Hair Follicles Grown In Vitro Experimental dermatology · 2003
    6. Formation and Structure of Human Hair Birkhäuser Basel eBooks · 1995