A Comprehensive Review of Genome-Wide Association Studies of Human Hair Traits

    Carli D. Needle, Anna Brinks, Olivia D. Perez … Lynn Petukhova
    Studysummary Genetic studies on hair traits can improve understanding of health and disease.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 36

    1. Evolution of Long Scalp Hair in Humans British Journal of Dermatology · 2025
    2. Deep Hair Phenomics: Implications in Endocrinology, Development, and Aging Journal of Investigative Dermatology · 2024
    3. From the Microscopic Sweat Gland to Large Datasets: The Power of Quantitative Traits in Dermatology Journal of Investigative Dermatology · 2024
    4. Human Hair Graying Revisited: Principles, Misconceptions, And Key Research Frontiers Journal of Investigative Dermatology · 2023
    5. Spatial Distribution and Functional Impact of Human Scalp Hair Follicle Microbiota Journal of Investigative Dermatology · 2023
    6. Beyond the Epidermal-Melanin-Unit: The Human Scalp Anagen Hair Bulb Is Home to Multiple Melanocyte Subpopulations of Variable Melanogenic Capacity International Journal of Molecular Sciences · 2023
    7. Human Scalp Hair as a Thermoregulatory Adaptation Proceedings of the National Academy of Sciences · 2023
    8. The Anti-Apoptotic Bcl-2 Protein Regulates Hair Follicle Stem Cell Function EMBO Reports · 2021
    9. High-Throughput Phenotyping Methods for Quantifying Hair Fiber Morphology Scientific Reports · 2021
    10. Hirsutism in Women: Causes, Diagnosis, and Treatment Options PubMed · 2019
    11. Hedgehog Stimulates Hair Follicle Neogenesis by Creating Inductive Dermis During Murine Skin Wound Healing Nature Communications · 2018
    12. Genome-Wide Association Study in Japanese Females Identifies Fifteen Novel Skin-Related Trait Associations Scientific reports · 2018
    13. Genome-Wide Association Meta-Analysis of Individuals of European Ancestry Identifies New Loci Explaining a Substantial Fraction of Hair Color Variation and Heritability Nature Genetics · 2018
    14. Androgens Trigger Different Growth Responses in Genetically Identical Human Hair Follicles in Organ Culture Reflecting Their Epigenetic Diversity in Life The FASEB Journal · 2017
    15. Androgens and Androgen Receptor Action in Skin and Hair Follicles Molecular and Cellular Endocrinology · 2017
    16. The Biology And Genetics Of Curly Hair Experimental Dermatology · 2017
    17. Touch Receptors Undergo Rapid Remodeling in Healthy Skin Cell Reports · 2016
    18. A Genome-Wide Association Scan in Admixed Latin Americans Identifies Loci Influencing Facial and Scalp Hair Features Nature Communications · 2016
    19. A Guide to Studying Human Hair Follicle Cycling In Vivo Journal of Investigative Dermatology · 2015
    20. An Integrated Transcriptome Atlas of Embryonic Hair Follicle Progenitors, Their Niche, and the Developing Skin Developmental cell · 2015
    21. The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle Cold Spring Harbor Perspectives in Medicine · 2014
    22. Trichohyalin-Like Proteins Have Evolutionarily Conserved Roles in the Morphogenesis of Skin Appendages Journal of Investigative Dermatology · 2014
    23. Epithelial Stem Cells And Implications For Wound Repair Seminars in Cell & Developmental Biology · 2012
    24. Mesenchymal–Epithelial Interactions During Hair Follicle Morphogenesis and Cycling Seminars in Cell & Developmental Biology · 2012
    25. Live Imaging of Stem Cell and Progeny Behavior in Physiological Hair-Follicle Regeneration Nature · 2012
    26. Trichohyalin Is a Potential Major Autoantigen in Human Alopecia Areata Journal of Proteome Research · 2010
    27. Intermediate Hair Follicles: A New, More Clinically Relevant Model for Hair Growth Investigations British Journal of Dermatology · 2010
    28. Common Variants in the Trichohyalin Gene Are Associated with Straight Hair in Europeans American journal of human genetics · 2009
    29. From Telogen to Exogen: Mechanisms Underlying Formation and Subsequent Loss of the Hair Club Fiber Journal of Investigative Dermatology · 2009
    30. Enhanced Ectodysplasin-A Receptor Signaling Alters Multiple Fiber Characteristics to Produce the East Asian Hair Form Human mutation · 2008
    31. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007
    32. Hormonal Regulation of Hair Follicles Exhibits a Biological Paradox Seminars in Cell & Developmental Biology · 2007
    33. Human Hair Follicles Display a Functional Equivalent of the Hypothalamic-Pituitary-Adrenal (HPA) Axis and Synthesize Cortisol The FASEB Journal · 2005
    34. Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis Journal of Clinical Investigation · 2001
    35. The Biology of Hair Follicles The New England Journal of Medicine · 1999
    36. Metabolism of Freshly Isolated Human Hair Follicles Capable of Hair Elongation: A Glutaminolytic, Aerobic Glycolytic Tissue Journal of Investigative Dermatology · 1993