Blimp1+ Cells Generate Functional Mouse Sebaceous Gland Organoids In Vitro

May 2019 in “ Nature communications ”

Alona Feldman, Dzmitry Mukha, Itzhak I. Maor, Egor Sedov, Elle Koren, Yahav Yosefzon, Tomer Shlomi, Yaron Fuchs

Blimp1+ cells sebaceous gland organoids sebocytes c-Myc acne vulgaris sebaceous gland acne

Studysummary This study found that Blimp1+ cells from mice can generate sebaceous gland organoids in vitro, which mimic natural gland traits and may aid in studying acne vulgaris.

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research Host-Microbiome Interactions and Recent Progress in Understanding the Biology of Acne Vulgaris

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This study examined recent findings on the role of host-microbiome interactions in acne, highlighting that the skin's microbiome composition differs between acne-affected and healthy individuals and discussing emerging microbiome-based treatments.

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research Isolation of Stem Cells and Progenitors from Mouse Epidermis

13 citations , May 2017 in “Current Protocols in Stem Cell Biology”

This study outlines a method to isolate hair follicle stem cells from mouse skin using fluorescence activated cell-sorting for use in research models, but reports no experimental findings.

research Hair Follicle Stem Cell Cultures Reveal Self-Organizing Plasticity of Stem Cells and Their Progeny

61 citations , December 2016 in “The EMBO Journal”

This study established a new in vitro culture system that supports the growth and dynamic self-organization of hair follicle stem cells and their progeny, promoting a stable population equilibrium.

research Isolating Hair Follicle Stem Cells and Epidermal Keratinocytes from Dorsal Mouse Skin

23 citations , April 2016 in “Journal of Visualized Experiments”

This research details a robust method for isolating hair follicle stem cells and epidermal keratinocytes from mouse hair follicles using fluorescence activated cell-sorting technology.

BLIMP1 Is Required for Postnatal Epidermal Homeostasis but Does Not Define a Sebaceous Gland Progenitor Under Steady-State Conditions

research BLIMP1 Is Required for Postnatal Epidermal Homeostasis but Does Not Define a Sebaceous Gland Progenitor Under Steady-State Conditions

50 citations , September 2014 in “Stem cell reports”

In this study, BLIMP1 was found to function in terminally differentiated epidermal cells to maintain homeostasis, rather than defining a sebocyte progenitor population.

research Plasticity of Epithelial Stem Cells in Tissue Regeneration

479 citations , June 2014 in “Science”

This review discusses the plasticity of epithelial stem cells in regenerative contexts and reports no new research findings; the authors highlight potential implications for regenerative medicine and cancer.

research Ligand-Independent Epidermal Growth Factor Receptor Hyperactivation Increases Sebaceous Gland Size and Sebum Secretion in Mice

22 citations , August 2013 in “Experimental Dermatology”

In this study, the researchers found that constitutive activation of the EGFR in mice led to increased sebum production, enlarged sebaceous glands, and altered gene expression related to sebocyte proliferation and lipogenesis.

research Sept4/ARTS Regulates Stem Cell Apoptosis and Skin Regeneration

78 citations , June 2013 in “Science”

This study found that mice lacking the Sept4/ARTS gene had more hair follicle stem cells and improved wound healing, suggesting apoptosis regulation as a potential target in regenerative medicine.

research C-MYC-Induced Sebaceous Gland Differentiation Is Controlled by an Androgen Receptor/p53 Axis

60 citations , February 2013 in “Cell reports”

This study demonstrates that c-MYC overexpression in sebaceous glands affects differentiation via a regulatory axis involving the androgen receptor and p53, influencing carcinoma formation outcomes.

research Development and Homeostasis of the Sebaceous Gland

107 citations , August 2012 in “Seminars in Cell & Developmental Biology”

This review discusses the role of signaling networks in sebaceous gland development and disorders, highlighting recent insights from mouse models and cell line studies, but reports no new experimental results.

research Scratching the Surface of Skin Development

788 citations , February 2007 in “Nature”

This review explores how adult skin epithelia preserve stem cell populations for hair follicle regeneration and wound healing, but reports no new experimental results.

research Bone Morphogenetic Protein Signaling Regulates Postnatal Hair Follicle Differentiation and Cycling

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research Deregulated Expression of c-Myc Depletes Epidermal Stem Cells

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research C-Myc Activation in Transgenic Mouse Epidermis Results in Mobilization of Stem Cells and Differentiation of Their Progeny

338 citations , April 2001 in “Current Biology”

This study found that transient activation of c-Myc in transgenic mice stimulates keratinocyte proliferation and sebocyte differentiation, affecting normal epidermal and hair follicle development.